1psl: Difference between revisions

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{{Theoretical_model}}
{{Theoretical_model}}
{{Seed}}
[[Image:1psl.png|left|200px]]


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==COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN==
The line below this paragraph, containing "STRUCTURE_1psl", creates the "Structure Box" on the page.
<StructureSection load='1psl' size='340' side='right'caption='[[1psl]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PSL FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1psl FirstGlance], [https://www.ebi.ac.uk/pdbsum/1psl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1psl ProSAT]</span></td></tr>
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</table>
{{STRUCTURE_1psl|  PDB=1psl  |  SCENE=  }}
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Structural and environmental constraints greatly simplify the folding problem for membrane proteins. Computational methods can be used in a global search to find a small number of chemically reasonable models within these constraints, such that a modest set of experimental data can distinguish among them. We show that, for phospholamban, the global search can be further simplified by reducing the problem to two-body, rather than many-body, interactions. This method of a constrained global search combined with experimental mutagenesis data yields a three-dimensional structure for this pentameric ion channel. The model is a left-handed symmetric homopentamer of alpha-helices with a well-defined channel, lined solely by hydrophobic residues.


===COMPUTATIONAL SEARCHING AND MUTAGENESIS SUGGEST A STRUCTURE FOR THE PENTAMERIC TRANSMEMBRANE DOMAIN OF PHOSPHOLAMBAN===
Computational searching and mutagenesis suggest a structure for the pentameric transmembrane domain of phospholamban.,Adams PD, Arkin IT, Engelman DM, Brunger AT Nat Struct Biol. 1995 Feb;2(2):154-62. PMID:7749920<ref>PMID:7749920</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 1psl" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 7749920 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_7749920}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Theoretical Model]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PSL OCA].
[[Category: Large Structures]]
 
==Reference==
<ref group="xtra">PMID:7749920</ref><references group="xtra"/>
[[Category: Adams, P D]]
[[Category: Adams, P D]]
[[Category: Arkin, I T]]
[[Category: Arkin, I T]]
[[Category: Brunger, A T]]
[[Category: Brunger, A T]]
[[Category: Engelman, D M]]
[[Category: Engelman, D M]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Apr  8 08:41:15 2010''
Retrieved from "https://proteopedia.org/1psl"