102d: Difference between revisions

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New page: left|200px<br /> <applet load="102d" size="450" color="white" frame="true" align="right" spinBox="true" caption="102d, resolution 2.200Å" /> '''SEQUENCE-DEPENDENT...
 
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[[Image:102d.gif|left|200px]]<br />
<applet load="102d" size="450" color="white" frame="true" align="right" spinBox="true"
caption="102d, resolution 2.200&Aring;" />
'''SEQUENCE-DEPENDENT DRUG BINDING TO THE MINOR GROOVE OF DNA: THE CRYSTAL STRUCTURE OF THE DNA DODECAMER D(CGCAAATTTGCG)2 COMPLEXED WITH PROPAMIDINE'''<br />


==Overview==
==SEQUENCE-DEPENDENT DRUG BINDING TO THE MINOR GROOVE OF DNA: THE CRYSTAL STRUCTURE OF THE DNA DODECAMER D(CGCAAATTTGCG)2 COMPLEXED WITH PROPAMIDINE==
The DNA-binding ligand propamidine, an analogue of the drug pentamidine, which is used in the treatment of acquired immune deficiency syndrome, (AIDS)-associated Pneumocystis carinii, has been cocrystallized with the, DNA sequence d(CGCAAATTTGCG)2, and the crystal structure of the complex, has been determined using data from 8 to 2.2 A resolution. The R factor, converged to 15.5% with the inclusion of 73 water molecules. The structure, shows binding of the propamidine molecule within the AT tract of the DNA, minor groove with a shift from the center of the duplex toward the 3' end, of ca. 2 A. The long AT tract of six base pairs in length allows the, propamidine many potential binding sites in the DNA groove, and its, binding is seen to occur where there is least perturbation to the DNA ... [[http://ispc.weizmann.ac.il/pmbin/getpm?7608897 (full description)]]
<StructureSection load='102d' size='340' side='right'caption='[[102d]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
 
== Structural highlights ==
==About this Structure==
<table><tr><td colspan='2'>[[102d]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=102D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=102D FirstGlance]. <br>
102D is a [[http://en.wikipedia.org/wiki/Protein_complex Protein complex]] structure of sequences from [[http://en.wikipedia.org/wiki/ ]] with TNT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id= OCA]].
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
 
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TNT:1,3-BIS(AMIDINOPHENOXY)PROPANE'>TNT</scene></td></tr>
==Reference==
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=102d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=102d OCA], [https://pdbe.org/102d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=102d RCSB], [https://www.ebi.ac.uk/pdbsum/102d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=102d ProSAT]</span></td></tr>
Sequence-dependent drug binding to the minor groove of DNA: crystal structure of the DNA dodecamer d(CGCAAATTTGCG)2 complexed with propamidine., Nunn CM, Neidle S, J Med Chem. 1995 Jun 23;38(13):2317-25. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7608897 7608897]
</table>
[[Category: Protein complex]]
__TOC__
[[Category: Neidle, S.]]
</StructureSection>
[[Category: Nunn, C.M.]]
[[Category: Large Structures]]
[[Category: TNT]]
[[Category: Neidle S]]
[[Category: b-dna]]
[[Category: Nunn CM]]
[[Category: complexed with drug]]
[[Category: double helix]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Oct 29 15:37:48 2007''

Latest revision as of 06:23, 7 February 2024

SEQUENCE-DEPENDENT DRUG BINDING TO THE MINOR GROOVE OF DNA: THE CRYSTAL STRUCTURE OF THE DNA DODECAMER D(CGCAAATTTGCG)2 COMPLEXED WITH PROPAMIDINE

102d, resolution 2.20Å

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