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[[Image:1gwz.gif|left|200px]]<br />
<applet load="1gwz" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1gwz, resolution 2.50&Aring;" />
'''CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1'''<br />


==Overview==
==CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1==
The crystal structures of the protein-tyrosine phosphatase SHP-1 catalytic, domain and the complex it forms with the substrate analogue tungstate have, been determined and refined to crystallographic R values of 0.209 at 2.5 A, resolution and 0.207 at 2.8 A resolution, respectively. Despite low, sequence similarity, the catalytic domain of SHP-1 shows high similarity, in secondary and tertiary structures with other protein-tyrosine, phosphatases (PTPs). In contrast to the conformational changes observed in, the crystal structures of PTP1B and Yersinia PTP, the WPD loop, (Trp419-Pro428) in the catalytic domain of SHP-1 moves away from the, substrate binding pocket after binding the tungstate ion. Sequence, alignment and structural analysis suggest that the residues in the WPD, loop, ... [[http://ispc.weizmann.ac.il/pmbin/getpm?9774441 (full description)]]
<StructureSection load='1gwz' size='340' side='right'caption='[[1gwz]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1gwz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GWZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GWZ FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gwz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gwz OCA], [https://pdbe.org/1gwz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gwz RCSB], [https://www.ebi.ac.uk/pdbsum/1gwz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gwz ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PTN6_HUMAN PTN6_HUMAN] Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.<ref>PMID:11266449</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gw/1gwz_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1gwz ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1GWZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]]. Active as [[http://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48]]. Structure known Active Site: WPD. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GWZ OCA]].
*[[Tyrosine phosphatase 3D structures|Tyrosine phosphatase 3D structures]]
 
== References ==
==Reference==
<references/>
Crystal structure of the catalytic domain of protein-tyrosine phosphatase SHP-1., Yang J, Liang X, Niu T, Meng W, Zhao Z, Zhou GW, J Biol Chem. 1998 Oct 23;273(43):28199-207. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9774441 9774441]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Protein-tyrosine-phosphatase]]
[[Category: Large Structures]]
[[Category: Single protein]]
[[Category: Liang X]]
[[Category: Liang, X.]]
[[Category: Meng W]]
[[Category: Meng, W.]]
[[Category: Niu T]]
[[Category: Niu, T.]]
[[Category: Yang J]]
[[Category: Yang, J.]]
[[Category: Zhao Z]]
[[Category: Zhao, Z.]]
[[Category: Zhou GW]]
[[Category: Zhou, G.W.]]
[[Category: catalytic domain]]
[[Category: hydrolase]]
[[Category: protein tyrosine phosphatase]]
[[Category: sh2 domain]]
[[Category: wpd loop]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 10:32:54 2007''

Latest revision as of 07:26, 7 February 2024

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF THE PROTEIN TYROSINE PHOSPHATASE SHP-1

1gwz, resolution 2.50Å

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