3l4n: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,615 edits
No edit summary
 
(6 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3l4n.png|left|200px]]


<!--
==Crystal structure of yeast monothiol glutaredoxin Grx6==
The line below this paragraph, containing "STRUCTURE_3l4n", creates the "Structure Box" on the page.
<StructureSection load='3l4n' size='340' side='right'caption='[[3l4n]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3l4n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3L4N FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GSH:GLUTATHIONE'>GSH</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
{{STRUCTURE_3l4n|  PDB=3l4n  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3l4n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3l4n OCA], [https://pdbe.org/3l4n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3l4n RCSB], [https://www.ebi.ac.uk/pdbsum/3l4n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3l4n ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLRX6_YEAST GLRX6_YEAST]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/l4/3l4n_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3l4n ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Glutaredoxins (Grxs) are a ubiquitous family of proteins that reduce disulfide bonds in substrate proteins using electrons from reduced glutathione (GSH). The yeast Saccharomyces cerevisiae Grx6 is a monothiol Grx that is localized in the endoplasmic reticulum and Golgi compartments. Grx6 consists of three segments, a putative signal peptide (M1-I36), an N-terminal domain (K37-T110), and a C-terminal Grx domain (K111-N231, designated Grx6C). Compared to the classic dithiol glutaredoxin Grx1, Grx6 has a lower glutathione disulfide reductase activity but a higher glutathione S-transferase activity. In addition, similar to human Grx2, Grx6 binds GSH via an iron-sulfur cluster in vitro. The N-terminal domain is essential for noncovalent dimerization, but not required for either of the above activities. The crystal structure of Grx6C at 1.5 A resolution revealed a novel two-strand antiparallel beta-sheet opposite the GSH binding groove. This extra beta-sheet might also exist in yeast Grx7 and in a group of putative Grxs in lower organisms, suggesting that Grx6 might represent the first member of a novel Grx subfamily.


===Crystal structure of yeast monothiol glutaredoxin Grx6===
Structural and biochemical characterization of yeast monothiol glutaredoxin Grx6.,Luo M, Jiang YL, Ma XX, Tang YJ, He YX, Yu J, Zhang RG, Chen Y, Zhou CZ J Mol Biol. 2010 May 14;398(4):614-22. Epub 2010 Mar 27. PMID:20347849<ref>PMID:20347849</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
<!--
</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20347849}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3l4n" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20347849 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20347849}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3L4N is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3L4N OCA].
[[Category: Saccharomyces cerevisiae S288C]]
 
[[Category: Chen Y]]
==Reference==
[[Category: He Y-X]]
<ref group="xtra">PMID:20347849</ref><references group="xtra"/>
[[Category: Jiang Y-L]]
[[Category: Glutathione-disulfide reductase]]
[[Category: Luo M]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Ma X-X]]
[[Category: Chen, Y.]]
[[Category: Tang Y-J]]
[[Category: He, Y X.]]
[[Category: Yu J]]
[[Category: Jiang, Y L.]]
[[Category: Zhang R-G]]
[[Category: Luo, M.]]
[[Category: Zhou C-Z]]
[[Category: Ma, X X.]]
[[Category: Tang, Y J.]]
[[Category: Yu, J.]]
[[Category: Zhang, R G.]]
[[Category: Zhou, C Z.]]
[[Category: C-terminal domain of grx6]]
[[Category: Oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:14:53 2010''

Latest revision as of 22:39, 26 March 2025

Crystal structure of yeast monothiol glutaredoxin Grx6

3l4n, resolution 1.50Å

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "https://proteopedia.org/index.php?title=3l4n&oldid=4318962"