3h44: Difference between revisions

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{{Seed}}
[[Image:3h44.jpg|left|200px]]


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==Crystal Structure of Insulin Degrading Enzyme in Complex with macrophage inflammatory protein 1 alpha==
The line below this paragraph, containing "STRUCTURE_3h44", creates the "Structure Box" on the page.
<StructureSection load='3h44' size='340' side='right'caption='[[3h44]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3h44]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H44 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3H44 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DIO:1,4-DIETHYLENE+DIOXIDE'>DIO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3h44| PDB=3h44 |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3h44 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3h44 OCA], [https://pdbe.org/3h44 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3h44 RCSB], [https://www.ebi.ac.uk/pdbsum/3h44 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3h44 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/IDE_HUMAN IDE_HUMAN] Plays a role in the cellular breakdown of insulin, IAPP, glucagon, bradykinin, kallidin and other peptides, and thereby plays a role in intercellular peptide signaling. Degrades amyloid formed by APP and IAPP. May play a role in the degradation and clearance of naturally secreted amyloid beta-protein by neurons and microglia.<ref>PMID:10684867</ref> <ref>PMID:17613531</ref> <ref>PMID:18986166</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/h4/3h44_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3h44 ConSurf].
<div style="clear:both"></div>


===Crystal Structure of Insulin Degrading Enzyme in Complex with macrophage inflammatory protein 1 alpha===
==See Also==
 
*[[Insulin-degrading enzyme 3D structures|Insulin-degrading enzyme 3D structures]]
 
== References ==
==About this Structure==
<references/>
3H44 is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3H44 OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Insulysin]]
[[Category: Large Structures]]
[[Category: Guo, Q.]]
[[Category: Guo Q]]
[[Category: Ren, M.]]
[[Category: Ren M]]
[[Category: Tang, W J.]]
[[Category: Tang WJ]]
[[Category: Chemotaxis]]
[[Category: Cytokine]]
[[Category: Cytoplasm]]
[[Category: Disulfide bond]]
[[Category: Hydrolase]]
[[Category: Hydrolase-cytokine complex]]
[[Category: Ide]]
[[Category: Inflammatory response]]
[[Category: Metal-binding]]
[[Category: Metalloprotease]]
[[Category: Mip1alpha]]
[[Category: Polymorphism]]
[[Category: Protease]]
[[Category: Secreted]]
[[Category: Zinc]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 14 09:49:10 2010''
Retrieved from "https://proteopedia.org/3h44"