2wsb: Difference between revisions

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{{Seed}}
[[Image:2wsb.jpg|left|200px]]


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==Crystal structure of the short-chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD==
The line below this paragraph, containing "STRUCTURE_2wsb", creates the "Structure Box" on the page.
<StructureSection load='2wsb' size='340' side='right'caption='[[2wsb]], [[Resolution|resolution]] 1.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2wsb]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Cereibacter_sphaeroides Cereibacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WSB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=POL:N-PROPANOL'>POL</scene></td></tr>
{{STRUCTURE_2wsb|  PDB=2wsb  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wsb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wsb OCA], [https://pdbe.org/2wsb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wsb RCSB], [https://www.ebi.ac.uk/pdbsum/2wsb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wsb ProSAT]</span></td></tr>
 
</table>
===CRYSTAL STRUCTURE OF THE SHORT-CHAIN DEHYDROGENASE GALACTITOL-DEHYDROGENASE (GATDH) OF RHODOBACTER SPHAEROIDES IN COMPLEX WITH NAD===
== Function ==
 
[https://www.uniprot.org/uniprot/GATDH_CERSP GATDH_CERSP] Catalyzes the interconversion of galactitol to the rare sugar L-tagatose (PubMed:7551050). Shows activity with a wide range of substrates, and catalyzes the oxidation of a variety of polyvalent aliphatic alcohols and polyols to the corresponding ketones and ketoses, respectively, and in the reverse reaction, it reduces ketones with high stereoselectivity yielding the corresponding S-configurated alcohols (PubMed:7551050, PubMed:15296184). Shows high activity with D-threitol, xylitol, 1,2-hexanediol, 1,2-pentanediol, 2-hexanol, L-erythrulose, D-ribulose and acetoin (PubMed:7551050). Specific for NAD(+) (PubMed:7551050).<ref>PMID:15296184</ref> <ref>PMID:7551050</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
2WSB is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Rhodobacter_sphaeroides Rhodobacter sphaeroides]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WSB OCA].  
Check<jmol>
[[Category: Galactitol 2-dehydrogenase]]
  <jmolCheckbox>
[[Category: Rhodobacter sphaeroides]]
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ws/2wsb_consurf.spt"</scriptWhenChecked>
[[Category: Carius, Y.]]
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
[[Category: Christian, H.]]
    <text>to colour the structure by Evolutionary Conservation</text>
[[Category: Faust, A.]]
  </jmolCheckbox>
[[Category: Giffhorn, F.]]
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wsb ConSurf].
[[Category: Kohring, G W.]]
<div style="clear:both"></div>
[[Category: Kornberger, P.]]
== References ==
[[Category: Scheidig, A J.]]
<references/>
[[Category: Oxidoreductase]]
__TOC__
[[Category: Rossmann fold]]
</StructureSection>
[[Category: Sdr]]
[[Category: Cereibacter sphaeroides]]
[[Category: Tagatose]]
[[Category: Large Structures]]
 
[[Category: Carius Y]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Apr 28 11:01:25 2010''
[[Category: Christian H]]
[[Category: Faust A]]
[[Category: Giffhorn F]]
[[Category: Kohring GW]]
[[Category: Kornberger P]]
[[Category: Scheidig AJ]]

Latest revision as of 07:10, 1 May 2024

Crystal structure of the short-chain dehydrogenase Galactitol- Dehydrogenase (GatDH) of Rhodobacter sphaeroides in complex with NAD

2wsb, resolution 1.25Å

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