User:Reuben Chacko: Difference between revisions

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One of the CBI Molecules related closely to studies being carried out at the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the [http://www.umass.edu/thaigroup/ Thayumanavan Research Group] and on display at the [http://molecularplayground.org/ Molecular Playground].
One of the CBI Molecules related closely to studies being carried out at the University of Massachusetts Amherst Chemistry-Biology Interface Program at UMass Amherst in the [http://www.umass.edu/thaigroup/ Thayumanavan Research Group] and on display at the [http://molecularplayground.org/ Molecular Playground].


=== Glutathione Reductase ===
{{Clear}}
<applet load='1GRE' size='[350,338]' frame='true' align='right'
caption='GSR with substrate glutathione disulfide and FAD cofactor' scene='User:Reuben_Chacko/Glutathione_reductase/6'/>


<applet load='1GRE' size='[350,338]' frame='true' align='right'
'''Glutathione Reductase'''  <scene name='User:Reuben_Chacko/Glutathione_reductase/6'> (GSR)</scene> - represented by green ribbons- breaks up  <scene name='User:Reuben_Chacko/Glutathione_disulfide/1'>glutathione disulfide</scene> (molecule with two yellow spheres shown in the 3D graphic) to  <scene name='User:Reuben_Chacko/Glutathione/2'> Glutathione</scene> (has only one yellow sphere).
caption='Glutathione reductase with substrate glutathione disulfide and flavin adenine dinucleotide as a cofactor' scene='User:/Sandbox_1/Loadedfrompdb/4'/>
Glutathione is an anti-oxidant molecule (which itself is made up of three amino acid molecules -glutamine, cystine and glycine) that keeps cells in "shape" ensuring other proteins in the cell soup don't get oxidized "burn up" and keep the cell machinery running.
 
<scene name='User:Reuben_Chacko/Glutathione_reductase/7'> Here </scene> flavin adenine dinucleotide <scene name='User:Reuben_Chacko/Fad/4'> (FAD)</scene> (flat molecule in the middle) another molecule that helps GSR to break glutathione disulfide bonds is juxtaposed up close to the glutathione disulfide molecule ready to break it up!


=== Ligand-binding domain ===
The tetrahedral structure floating besides glutathione disulfide and FAD is a phosphate ion representing NADPH (another molecule involved in this process) in the crystal structure.


Molecular Playground Banner: "Molecules that protect your cells from burning up"




(<scene name='User:Reuben_Chacko/Glutathione_reductase/6'>TextToBeDisplayed</scene> )


Molecular Playground banner:
[http://en.wikipedia.org/wiki/Glutathione_reductase Wikipedia page on GSR]
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