2xd7: Difference between revisions

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'''Unreleased structure'''


The entry 2xd7 is ON HOLD
==Crystal structure of the macro domain of human core histone H2A==
<StructureSection load='2xd7' size='340' side='right'caption='[[2xd7]], [[Resolution|resolution]] 2.09&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2xd7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XD7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XD7 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.09&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xd7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xd7 OCA], [https://pdbe.org/2xd7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xd7 RCSB], [https://www.ebi.ac.uk/pdbsum/2xd7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xd7 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/H2AW_HUMAN H2AW_HUMAN] Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.<ref>PMID:15621527</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xd7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xd7 ConSurf].
<div style="clear:both"></div>


Authors: Vollmar, M., Philipps, C., Carpenter, L., Muniz, J.R.C., Krojer, T., Ugochukwu, E., Von Delft, F., Bountra, C., Arrowsmith, C.H., Weigelt, J., Edwards, A., Gileadi, O.
==See Also==
 
*[[Histone 3D structures|Histone 3D structures]]
Description: Crystal structure of the macro domain of human core histone H2A
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed May 12 10:40:30 2010''
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Arrowsmith CH]]
[[Category: Bountra C]]
[[Category: Carpenter EP]]
[[Category: Edwards A]]
[[Category: Gileadi O]]
[[Category: Krojer T]]
[[Category: Muniz JRC]]
[[Category: Phillips C]]
[[Category: Ugochukwu E]]
[[Category: Vollmar M]]
[[Category: Weigelt J]]
[[Category: Von Delft F]]
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