3m2e: Difference between revisions

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{{Seed}}
[[Image:3m2e.jpg|left|200px]]


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==Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate==
The line below this paragraph, containing "STRUCTURE_3m2e", creates the "Structure Box" on the page.
<StructureSection load='3m2e' size='340' side='right'caption='[[3m2e]], [[Resolution|resolution]] 1.40&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3m2e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M2E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M2E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.4&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_3m2e|  PDB=3m2e  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m2e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m2e OCA], [https://pdbe.org/3m2e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m2e RCSB], [https://www.ebi.ac.uk/pdbsum/3m2e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m2e ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CCPR_YEAST CCPR_YEAST] Destroys radicals which are normally produced within the cells and which are toxic to biological systems.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m2/3m2e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m2e ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The ferryl [Fe(IV)O] intermediate is important in many heme enzymes, and thus, the precise nature of the Fe(IV)-O bond is critical in understanding enzymatic mechanisms. The 1.40 A crystal structure of cytochrome c peroxidase Compound I has been determined as a function of X-ray dose while the visible spectrum was being monitored. The Fe-O bond increases in length from 1.73 A in the low-X-ray dose structure to 1.90 A in the high-dose structure. The low-dose structure correlates well with an Fe(IV) horizontal lineO bond, while we postulate that the high-dose structure is the cryo-trapped Fe(III)-OH species previously thought to be an Fe(IV)-OH species.


===Crystallographic and Single Crystal Spectral Analysis of the Peroxidase Ferryl Intermediate===
Crystallographic and single-crystal spectral analysis of the peroxidase ferryl intermediate.,Meharenna YT, Doukov T, Li H, Soltis SM, Poulos TL Biochemistry. 2010 Apr 13;49(14):2984-6. PMID:20230048<ref>PMID:20230048</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3m2e" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_20230048}}, adds the Publication Abstract to the page
*[[Cytochrome c peroxidase 3D structures|Cytochrome c peroxidase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 20230048 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20230048}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
3M2E is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M2E OCA].
 
==Reference==
<ref group="xtra">PMID:20230048</ref><references group="xtra"/>
[[Category: Cytochrome-c peroxidase]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Meharenna, Y T.]]
[[Category: Meharenna YT]]
[[Category: Poulos, T L.]]
[[Category: Poulos TL]]
[[Category: Heme]]
[[Category: Hydrogen peroxide]]
[[Category: Iron]]
[[Category: Metal-binding]]
[[Category: Mitochondrion]]
[[Category: Organic radical]]
[[Category: Oxidoreductase]]
[[Category: Peroxidase]]
 
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Retrieved from "https://proteopedia.org/3m2e"