3m4d: Difference between revisions

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{{Seed}}
[[Image:3m4d.png|left|200px]]


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==Crystal structure of the M113N mutant of alpha-hemolysin==
The line below this paragraph, containing "STRUCTURE_3m4d", creates the "Structure Box" on the page.
<StructureSection load='3m4d' size='340' side='right'caption='[[3m4d]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3m4d]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4D FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4d OCA], [https://pdbe.org/3m4d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4d RCSB], [https://www.ebi.ac.uk/pdbsum/3m4d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4d ProSAT]</span></td></tr>
{{STRUCTURE_3m4d| PDB=3m4d |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m4d_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m4d ConSurf].
<div style="clear:both"></div>


===Crystal structure of the M113N mutant of alpha-hemolysin===
==See Also==
 
*[[Hemolysin 3D structures|Hemolysin 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_20400691}}, adds the Publication Abstract to the page
[[Category: Large Structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 20400691 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20400691}}
 
==About this Structure==
3M4D is a 7 chains structure with sequences from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4D OCA].
 
==Reference==
<ref group="xtra">PMID:20400691</ref><references group="xtra"/>
[[Category: Staphylococcus aureus]]
[[Category: Staphylococcus aureus]]
[[Category: Gouaux, E.]]
[[Category: Gouaux E]]
[[Category: Montoya, M.]]
[[Category: Montoya M]]
[[Category: Beta-barrel]]
[[Category: Cell invasion]]
[[Category: Cytolysis]]
[[Category: Cytolytic protein]]
[[Category: Hemolysis]]
[[Category: Secreted]]
[[Category: Toxin]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu May 20 09:06:47 2010''
Retrieved from "https://proteopedia.org/3m4d"