2xdp: Difference between revisions

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{{Seed}}
[[Image:2xdp.jpg|left|200px]]


<!--
==Crystal structure of the tudor domain of human JMJD2C==
The line below this paragraph, containing "STRUCTURE_2xdp", creates the "Structure Box" on the page.
<StructureSection load='2xdp' size='340' side='right'caption='[[2xdp]], [[Resolution|resolution]] 1.56&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2xdp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XDP FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.56&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_2xdp| PDB=2xdp |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xdp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xdp OCA], [https://pdbe.org/2xdp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xdp RCSB], [https://www.ebi.ac.uk/pdbsum/2xdp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xdp ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KDM4C_HUMAN KDM4C_HUMAN] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate.<ref>PMID:16603238</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xd/2xdp_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xdp ConSurf].
<div style="clear:both"></div>


===CRYSTAL STRUCTURE OF THE TUDOR DOMAIN OF HUMAN JMJD2C===
==See Also==
 
*[[Jumonji domain-containing protein 3D structures|Jumonji domain-containing protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
2XDP is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XDP OCA].
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Allerston, C.]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C.]]
[[Category: Allerston C]]
[[Category: Bountra, C.]]
[[Category: Arrowsmith C]]
[[Category: Chaikuad, A.]]
[[Category: Bountra C]]
[[Category: Daniel, M.]]
[[Category: Chaikuad A]]
[[Category: Edwards, A.]]
[[Category: Daniel M]]
[[Category: Gileadi, C.]]
[[Category: Edwards A]]
[[Category: Krojer, T.]]
[[Category: Gileadi C]]
[[Category: Oppermann, U.]]
[[Category: Krojer T]]
[[Category: Phillips, C.]]
[[Category: Oppermann U]]
[[Category: Ugochukwu, E.]]
[[Category: Phillips C]]
[[Category: Vondelft, F.]]
[[Category: Ugochukwu E]]
[[Category: Weigelt, J.]]
[[Category: Weigelt J]]
[[Category: Weisbach, H.]]
[[Category: Weisbach H]]
[[Category: Yue, W W.]]
[[Category: Yue WW]]
[[Category: Histone modification]]
[[Category: Von Delft F]]
[[Category: Oxidoreductase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 10 11:13:12 2010''
Retrieved from "https://proteopedia.org/2xdp"