3m4w: Difference between revisions

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{{Seed}}
[[Image:3m4w.png|left|200px]]


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==Structural basis for the negative regulation of bacterial stress response by RseB==
The line below this paragraph, containing "STRUCTURE_3m4w", creates the "Structure Box" on the page.
<StructureSection load='3m4w' size='340' side='right'caption='[[3m4w]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3m4w]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M4W FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3m4w|  PDB=3m4w  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m4w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m4w OCA], [https://pdbe.org/3m4w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m4w RCSB], [https://www.ebi.ac.uk/pdbsum/3m4w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m4w ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/RSEB_ECOLI RSEB_ECOLI] Seems to modulate the activity of RpoE (sigma-E).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m4/3m4w_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m4w ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The sigmaE-dependent stress response in bacterial cells is initiated by the DegS- and RseP-regulated intramembrane proteolysis of a membrane-spanning antisigma factor, RseA. RseB binds to RseA and inhibits its sequential cleavage, thereby functioning as a negative modulator of this response. In the crystal structure of the periplasmic domain of RseA bound to RseB, the DegS cleavage site of RseA is unstructured, however, its P1 residue is buried in the hydrophobic pocket of RseB, which suggests that RseB binding blocks the access of DegS to the cleavage site.


===Structural basis for the negative regulation of bacterial stress response by RseB===
Structural basis for the negative regulation of bacterial stress response by RseB.,Kim DY, Kwon E, Choi J, Hwang HY, Kim KK Protein Sci. 2010 Jun;19(6):1258-63. PMID:20512978<ref>PMID:20512978</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_20512978}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3m4w" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20512978 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20512978}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Escherichia coli K-12]]
3M4W is a 8 chains structure with sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M4W OCA].
[[Category: Large Structures]]
 
[[Category: Choi JK]]
==Reference==
[[Category: Hwang H-Y]]
<ref group="xtra">PMID:20512978</ref><references group="xtra"/>
[[Category: Kim DY]]
[[Category: Escherichia coli]]
[[Category: Kim KK]]
[[Category: Choi, J K.]]
[[Category: Kwon E]]
[[Category: Hwang, H Y.]]
[[Category: Kim, D Y.]]
[[Category: Kim, K K.]]
[[Category: Kwon, E.]]
[[Category: Cell membrane]]
[[Category: Periplasm]]
[[Category: Rsea]]
[[Category: Rseb]]
[[Category: Rsep]]
[[Category: Sigma factor]]
[[Category: Signaling protein-signaling protein complex]]
[[Category: Stress response]]
[[Category: Transmembrane]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 16 08:17:22 2010''

Latest revision as of 16:29, 1 November 2023

Structural basis for the negative regulation of bacterial stress response by RseB

3m4w, resolution 2.30Å

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