3iwx: Difference between revisions

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{{Seed}}
[[Image:3iwx.png|left|200px]]


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==Crystal structure of cisplatin bound to a human copper chaperone (dimer)==
The line below this paragraph, containing "STRUCTURE_3iwx", creates the "Structure Box" on the page.
<StructureSection load='3iwx' size='340' side='right'caption='[[3iwx]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3iwx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IWX FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CPT:CISPLATIN'>CPT</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3iwx|  PDB=3iwx  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3iwx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3iwx OCA], [https://pdbe.org/3iwx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3iwx RCSB], [https://www.ebi.ac.uk/pdbsum/3iwx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3iwx ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/iw/3iwx_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3iwx ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways.


===Crystal structure of cisplatin bound to a human copper chaperone (dimer)===
Crystal structures of cisplatin bound to a human copper chaperone.,Boal AK, Rosenzweig AC J Am Chem Soc. 2009 Oct 14;131(40):14196-7. PMID:19807176<ref>PMID:19807176</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
The line below this paragraph, {{ABSTRACT_PUBMED_19807176}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3iwx" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 19807176 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19807176}}
__TOC__
 
</StructureSection>
==About this Structure==
3IWX is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IWX OCA].
 
==Reference==
<ref group="xtra">PMID:19807176</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Boal, A K.]]
[[Category: Large Structures]]
[[Category: Rosenzweig, A C.]]
[[Category: Boal AK]]
[[Category: Beta-alpha-beta-beta-alpha-beta]]
[[Category: Rosenzweig AC]]
[[Category: Chaperone]]
[[Category: Cisplatin]]
[[Category: Copper]]
[[Category: Copper transport]]
[[Category: Ion transport]]
[[Category: Metal transport]]
[[Category: Metal-binding]]
[[Category: Platinum]]
[[Category: Transport]]
[[Category: Transport protein]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jun 23 08:37:42 2010''

Latest revision as of 09:31, 13 August 2026

Crystal structure of cisplatin bound to a human copper chaperone (dimer)

3iwx, resolution 2.14Å

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