3ngo: Difference between revisions
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New page: '''Unreleased structure''' The entry 3ngo is ON HOLD Authors: Wang, H., Morita, M., Yang, W., Bartlam, M., Yamamoto, T., Rao, Z. Description: Crystal structure of the human CNOT6L nucl... |
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==Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA== | |||
<StructureSection load='3ngo' size='340' side='right'caption='[[3ngo]], [[Resolution|resolution]] 2.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ngo]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NGO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NGO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ngo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ngo OCA], [https://pdbe.org/3ngo PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ngo RCSB], [https://www.ebi.ac.uk/pdbsum/3ngo PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ngo ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CNO6L_HUMAN CNO6L_HUMAN] Plays a role in the deadenylation of mRNAs in the cytoplasm. Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA.<ref>PMID:17452450</ref> | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ng/3ngo_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ngo ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Bartlam M]] | |||
[[Category: Morita M]] | |||
[[Category: Rao Z]] | |||
[[Category: Wang H]] | |||
[[Category: Yamamoto T]] | |||
[[Category: Yang W]] | |||
Latest revision as of 08:32, 20 March 2024
Crystal structure of the human CNOT6L nuclease domain in complex with poly(A) DNA
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