2l00: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l00 is ON HOLD Authors: Garner, T.P., Long, J.E., Searle, M.S., Layfield, R. Description: Solution structure of the non-covalent complex of the ZN... |
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==Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin== | |||
<StructureSection load='2l00' size='340' side='right'caption='[[2l00]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L00 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l00 OCA], [https://pdbe.org/2l00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l00 RCSB], [https://www.ebi.ac.uk/pdbsum/2l00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l00 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ZFAN5_RAT ZFAN5_RAT] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity). | |||
==See Also== | |||
*[[3D structures of ubiquitin|3D structures of ubiquitin]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Rattus norvegicus]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Garner TP]] | |||
[[Category: Layfield R]] | |||
[[Category: Long JE]] | |||
[[Category: Searle MS]] | |||
Latest revision as of 06:50, 1 May 2024
Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin
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