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==Related PDB entries==
<StructureSection load='3iep' size='350' side='right' scene='Luciferase/Cv/1' caption='Luciferase (PDB code [[3iep]])'>
*[[1ba3]] firefly luciferase enzyme from ''Photinus pyralis''
== Function ==
*[[2psd]], [[2pse]], [[2psf]], [[2psh]], [[2psj]], and [[2psl]] the luciferase from ''Renilla reniformis'' (RLuc)
[[Luciferase]] (Luc) or '''luciferin monooxygenase''' (Lucmo)is an oxidative enzyme used in bioluminescence.  It catalyzes the oxidation of the pigment luciferin producing oxyluciferin and light<ref>PMID:2030669</ref>.  See detailed analysis in<br />
*[[1brl]] bacteria<nowiki>Insert non-formatted text here</nowiki>l luciferase from ''Vibrio harveyi''
* [[Luciola cruciata luciferase]]<br />
*[[1xkj]] bacterial luciferase from ''Vibrio harveyi''
* [[Luciferase FMN complex- Vibrio harveyi]]<br />
*[[2d1s]] thermostable Japanese Firefly Luciferase complexed with High-energy intermediate analogue
* [[Dinoflagellate luciferase]]<br />
*[[2d1t]] thermostable Japanese Firefly Luciferase red-color emission S286N mutant
* [[Luciferase (Hebrew)]].
*[[1BSL]]


==See Also==
See [[Colored & Bioluminescent Protein]].
 
== Relevance ==
Luc is used in biological research to assess gene transfection into cells where the Luc gene is added to the transfected gene and the light emission by Luc measured for indication of the transfection success<ref>PMID:3072883</ref>.  '''NanoLuc luciferase''' is a small mutated luciferase from shrimp with enhanced stability and a significant increase in luminescence <ref>PMID:27045664</ref>.
 
== 3D Structures of Luciferase ==
[[Luciferase 3D structures]]
 
</StructureSection>
 
==Additional information==
[[Image:2d1s jena3dviewer image.jpg|left|220px]]
<scene name='Luciferase/2d1s/1'>Luciferase</scene> ([[Luciola cruciata luciferase|2d1s]]) {{Link Toggle FancyCartoonHighQualityView}}
 
 
Several organisms are bioluminescent, meaning that they produce light. Luciferase is one of the enzymes that catalyzes light emitting reactions in organisms.
{{Clear}}
 
* For additional information, see: [[Colored & Bioluminescent Proteins]]
 
==References==
{{Reflist}}
 
 
==Additional Literature==
<ref group="xtra">PMID: 18949818</ref><ref group="xtra">PMID: 19859663</ref><references group="xtra"/>
 
==External Resources==
* [http://news.yahoo.com/s/ap/20100911/ap_on_re_us/us_fireflies_military_research Yahoo news coverage of luciferase studies funded research for military applications]
* [http://en.wikipedia.org/wiki/Luciferase Luciferase at Wikipedia]
* [http://en.wikipedia.org/wiki/Luciferase Luciferase at Wikipedia]
* *[http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb78_1.html Luciferase: June 2006 Molecule of the Month] as part of the series of tutorials that are at [http://www.pdb.org/pdb/home/home.do the RCSB Protein Data Bank] and written by [[User:David_S._Goodsell|David S. Goodsell]]
* [http://www.pdb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb78_1.html Luciferase: June 2006 Molecule of the Month] as part of the series of tutorials that are at [http://www.pdb.org/pdb/home/home.do the RCSB Protein Data Bank] and written by [[User:David_S._Goodsell|David S. Goodsell]]
 
[[Category: Photinus pyralis]]
[[Category: Renilla reniformis]]
[[Category: Renilla-luciferin 2-monooxygenase]]
[[Category: Luciola cruciata]]
[[Category: Luciferase]]
[[Category: Atp-binding]]
[[Category: Luminescence]]
[[Category: Magnesium]]
[[Category: Metal-binding]]
[[Category: Monooxygenase]]
[[Category: Nucleotide-binding]]
[[Category: Oxidoreductase]]
[[Category: Peroxisome]]
[[Category: Photoprotein]]
[[Category: Alpha/beta-hydrolase]]
[[Category:Topic Page]]

Latest revision as of 07:42, 11 July 2024

Luciferase (PDB code 3iep)

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Additional information

Luciferase (Luciola cruciata luciferase)


Several organisms are bioluminescent, meaning that they produce light. Luciferase is one of the enzymes that catalyzes light emitting reactions in organisms.

References


Additional Literature

  1. Marques SM, Esteves da Silva JC. Firefly bioluminescence: a mechanistic approach of luciferase catalyzed reactions. IUBMB Life. 2009 Jan;61(1):6-17. PMID:18949818 doi:10.1002/iub.134
  2. Inouye S. Firefly luciferase: an adenylate-forming enzyme for multicatalytic functions. Cell Mol Life Sci. 2010 Feb;67(3):387-404. Epub 2009 Oct 27. PMID:19859663 doi:10.1007/s00018-009-0170-8

External Resources

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