3n3z: Difference between revisions
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==Crystal structure of PDE9A (E406A) mutant in complex with IBMX== | |||
<StructureSection load='3n3z' size='340' side='right'caption='[[3n3z]], [[Resolution|resolution]] 2.75Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3n3z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N3Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N3Z FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.75Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=IBM:3-ISOBUTYL-1-METHYLXANTHINE'>IBM</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n3z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n3z OCA], [https://pdbe.org/3n3z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n3z RCSB], [https://www.ebi.ac.uk/pdbsum/3n3z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n3z ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PDE9A_HUMAN PDE9A_HUMAN] Hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes.<ref>PMID:18757755</ref> | |||
==See Also== | |||
*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen Y]] | |||
[[Category: Hou J]] | |||
[[Category: Luo H-B]] | |||
[[Category: Xu J]] | |||
[[Category: Zhao R]] | |||
[[Category: Zou L]] | |||
Latest revision as of 16:43, 1 November 2023
Crystal structure of PDE9A (E406A) mutant in complex with IBMX
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