3nti: Difference between revisions
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New page: '''Unreleased structure''' The entry 3nti is ON HOLD Authors: Liu, H.P., Huang, Y , Li, Z.Z. , Gong, W.M. , Xu, R.M. Description: Crystal structure of Tud11 and Aub[R15(me2s)] complex ... |
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==Crystal structure of Tudor and Aubergine [R15(me2s)] complex== | |||
<StructureSection load='3nti' size='340' side='right'caption='[[3nti]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3nti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTI FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nti OCA], [https://pdbe.org/3nti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nti RCSB], [https://www.ebi.ac.uk/pdbsum/3nti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nti ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TUD_DROME TUD_DROME] Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/3nti_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nti ConSurf]. | |||
<div style="clear:both"></div> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general. | |||
Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.,Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM Genes Dev. 2010 Sep 1;24(17):1876-81. Epub 2010 Aug 16. PMID:20713507<ref>PMID:20713507</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 3nti" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Drosophila melanogaster]] | |||
[[Category: Large Structures]] | |||
[[Category: Gong WM]] | |||
[[Category: Huang Y]] | |||
[[Category: Li ZZ]] | |||
[[Category: Liu HP]] | |||
[[Category: Xu RM]] | |||
Latest revision as of 16:51, 1 November 2023
Crystal structure of Tudor and Aubergine [R15(me2s)] complex
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