3liy: Difference between revisions

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{{Seed}}
[[Image:3liy.jpg|left|200px]]


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==crystal structure of HTLV protease complexed with Statine-containing peptide inhibitor==
The line below this paragraph, containing "STRUCTURE_3liy", creates the "Structure Box" on the page.
<StructureSection load='3liy' size='340' side='right'caption='[[3liy]], [[Resolution|resolution]] 1.86&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3liy]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_T-cell_leukemia_virus_type_I Human T-cell leukemia virus type I]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3LIY FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.86&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=STA:STATINE'>STA</scene></td></tr>
{{STRUCTURE_3liy|  PDB=3liy  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3liy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3liy OCA], [https://pdbe.org/3liy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3liy RCSB], [https://www.ebi.ac.uk/pdbsum/3liy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3liy ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q82134_9DELA Q82134_9DELA]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/li/3liy_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3liy ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Human T-cell leukemia virus type 1 (HTLV-1) is a retrovirus associated with several serious diseases, such as adult T-cell leukemia and tropical spastic paraparesis/myelopathy. For a number of years, the protease (PR) encoded by HTLV-1 has been a target for designing antiviral drugs, but that effort was hampered by limited available structural information. We report a high-resolution crystal structure of HTLV-1 PR complexed with a statine-containing inhibitor, a significant improvement over the previously available moderate-resolution structure. We also report crystal structures of the complexes of HTLV-1 PR with five different inhibitors that are more compact and more potent. A detailed study of structure-activity relationships was performed to interpret in detail the influence of the polar and hydrophobic interactions between the inhibitors and the protease.


===crystal structure of HTLV protease complexed with Statine-containing peptide inhibitor===
Crystal structures of inhibitor complexes of human T-cell leukemia virus (HTLV-1) protease.,Satoh T, Li M, Nguyen JT, Kiso Y, Gustchina A, Wlodawer A J Mol Biol. 2010 Aug 27;401(4):626-41. Epub 2010 Jun 30. PMID:20600105<ref>PMID:20600105</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3liy" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_20600105}}, adds the Publication Abstract to the page
*[[Virus protease 3D structures|Virus protease 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 20600105 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20600105}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Human T-cell leukemia virus type I]]
3LIY is a 6 chains structure with sequences from [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LIY OCA].
[[Category: Large Structures]]
 
[[Category: Gustchina A]]
==Reference==
[[Category: Kiso Y]]
<ref group="xtra">PMID:20600105</ref><references group="xtra"/>
[[Category: Li M]]
[[Category: Human t-lymphotropic virus 1]]
[[Category: Nguyen J]]
[[Category: Gustchina, A.]]
[[Category: Satoh T]]
[[Category: Kiso, Y.]]
[[Category: Wlodawer A]]
[[Category: Li, M.]]
[[Category: Nguyen, J.]]
[[Category: Satoh, T.]]
[[Category: Wlodawer, A.]]
[[Category: Hydrolase]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Statine]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:20:05 2010''

Latest revision as of 06:26, 27 November 2024

crystal structure of HTLV protease complexed with Statine-containing peptide inhibitor

3liy, resolution 1.86Å

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