3n1e: Difference between revisions

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{{Seed}}
[[Image:3n1e.jpg|left|200px]]


<!--
==Vps54 C-terminal domain==
The line below this paragraph, containing "STRUCTURE_3n1e", creates the "Structure Box" on the page.
<StructureSection load='3n1e' size='340' side='right'caption='[[3n1e]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3n1e]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N1E FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.702&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
{{STRUCTURE_3n1e| PDB=3n1e |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n1e OCA], [https://pdbe.org/3n1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n1e RCSB], [https://www.ebi.ac.uk/pdbsum/3n1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n1e ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/VPS54_MOUSE VPS54_MOUSE] Note=Defects in Vps54 are the cause of wobbler phenotype (wr). Wr is autosomal recessive and is a spontaneous mutation discovered almost 50 years ago. It causes spinal muscular atrophy and defective spermiogenesis.<ref>PMID:16244655</ref>
== Function ==
[https://www.uniprot.org/uniprot/VPS54_MOUSE VPS54_MOUSE] May be involved in retrograde transport from early and late endosomes to the late Golgi. The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD (By similarity).
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n1/3n1e_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n1e ConSurf].
<div style="clear:both"></div>


===Vps54 C-terminal domain===
==See Also==
 
*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
 
== References ==
==About this Structure==
<references/>
3N1E is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N1E OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Abascal-Palacios, G.]]
[[Category: Abascal-Palacios G]]
[[Category: Bonifacino, J S.]]
[[Category: Bonifacino JS]]
[[Category: Hierro, A.]]
[[Category: Hierro A]]
[[Category: Kajava, A.]]
[[Category: Kajava A]]
[[Category: Perez-Victoria, F J.]]
[[Category: Perez-Victoria FJ]]
[[Category: Pioro, E P.]]
[[Category: Pioro EP]]
[[Category: Tascon, I.]]
[[Category: Tascon I]]
[[Category: Garp.]]
[[Category: Golgi apparatus]]
[[Category: Spinal muscular atrophy]]
[[Category: Tethering complex]]
[[Category: Transport protein]]
[[Category: Vesicle trafficking]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 14 16:22:39 2010''
Retrieved from "https://proteopedia.org/3n1e"