3nwt: Difference between revisions
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New page: '''Unreleased structure''' The entry 3nwt is ON HOLD Authors: Mitchell, M.T., Smith, J.S., Mason, M., Harper, S., Speicher, D.W., Johnson, F.B., Skordalakes, E. Description: CDC13N Cry... |
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==Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13== | |||
<StructureSection load='3nwt' size='340' side='right'caption='[[3nwt]], [[Resolution|resolution]] 2.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3nwt]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NWT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NWT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nwt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nwt OCA], [https://pdbe.org/3nwt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nwt RCSB], [https://www.ebi.ac.uk/pdbsum/3nwt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nwt ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Harper S]] | |||
[[Category: Johnson FB]] | |||
[[Category: Mason M]] | |||
[[Category: Mitchell MT]] | |||
[[Category: Skordalakes E]] | |||
[[Category: Smith JS]] | |||
[[Category: Speicher DW]] | |||
Latest revision as of 10:01, 14 February 2024
Crystal structure of the N-terminal domain of the yeast telomere-binding and telomerase regulatory protein Cdc13
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