3gab: Difference between revisions

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{{Seed}}
[[Image:3gab.jpg|left|200px]]


<!--
==C-terminal domain of Bacillus subtilis MutL crystal form I==
The line below this paragraph, containing "STRUCTURE_3gab", creates the "Structure Box" on the page.
<StructureSection load='3gab' size='340' side='right'caption='[[3gab]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3gab]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3GAB FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3gab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3gab OCA], [https://pdbe.org/3gab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3gab RCSB], [https://www.ebi.ac.uk/pdbsum/3gab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3gab ProSAT]</span></td></tr>
{{STRUCTURE_3gab| PDB=3gab |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/MUTL_BACSU MUTL_BACSU] This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity). Overexpression of mutSL partially suppresses the high spontaneous mutation frequency of a ytkD/mutM/yfhQ triple disruption which lacks the system required to prevent damage by oxidized guanine (8-oxo-dGTP). This suggests that MutSL also functions to repair mismatches due to oxidative stress in both growing and stationary phase cells.<ref>PMID:19011023</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ga/3gab_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3gab ConSurf].
<div style="clear:both"></div>


===C-terminal domain of Bacillus subtilis MutL crystal form I===
==See Also==
 
*[[DNA mismatch repair protein 3D structures|DNA mismatch repair protein 3D structures]]
 
== References ==
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The line below this paragraph, {{ABSTRACT_PUBMED_20603082}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 20603082 is the PubMed ID number.
</StructureSection>
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{{ABSTRACT_PUBMED_20603082}}
 
==About this Structure==
3GAB is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3GAB OCA].
 
==Reference==
<ref group="xtra">PMID:20603082</ref><references group="xtra"/>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Chung, Y S.]]
[[Category: Large Structures]]
[[Category: Friedhoff, P.]]
[[Category: Chung YS]]
[[Category: Guarne, A.]]
[[Category: Friedhoff P]]
[[Category: Lorenowicz, J J.]]
[[Category: Guarne A]]
[[Category: Mitchell, R R.]]
[[Category: Lorenowicz JJ]]
[[Category: Pillon, M C.]]
[[Category: Mitchell RR]]
[[Category: Dna damage]]
[[Category: Pillon MC]]
[[Category: Dna repair]]
[[Category: Endonuclease activity]]
[[Category: Hydrolase]]
[[Category: Mismatch repair]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:15:44 2010''
Retrieved from "https://proteopedia.org/3gab"