3n9u: Difference between revisions

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{{Seed}}
[[Image:3n9u.jpg|left|200px]]


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==Crystal Structure of the Complex between the 25 kDa Subunit and the 59 kDa Subunit (RRM domain) of Human Cleavage Factor Im==
The line below this paragraph, containing "STRUCTURE_3n9u", creates the "Structure Box" on the page.
<StructureSection load='3n9u' size='340' side='right'caption='[[3n9u]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3n9u]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N9U FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
{{STRUCTURE_3n9u|  PDB=3n9u  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n9u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n9u OCA], [https://pdbe.org/3n9u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n9u RCSB], [https://www.ebi.ac.uk/pdbsum/3n9u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n9u ProSAT]</span></td></tr>
 
</table>
===Crystal Structure of the Complex between the 25 kDa Subunit and the 59 kDa Subunit (RRM domain) of Human Cleavage Factor Im===
== Function ==
 
[https://www.uniprot.org/uniprot/CPSF5_HUMAN CPSF5_HUMAN] Component of the cleavage factor Im (CFIm) complex that plays a key role in pre-mRNA 3'-processing. Involved in association with CPSF6 or CPSF7 in pre-MRNA 3'-end poly(A) site cleavage and poly(A) addition. NUDT21/CPSF5 binds to cleavage and polyadenylation RNA substrates. The homodimer mediates simultaneous sequence-specific recognition of two 5'-UGUA-3' elements within the pre-mRNA. Binds to, but does not hydrolyze mono- and di-adenosine nucleotides. May have a role in mRNA export.<ref>PMID:9659921</ref> <ref>PMID:8626397</ref> <ref>PMID:14690600</ref> <ref>PMID:20695905</ref> <ref>PMID:20479262</ref> <ref>PMID:21295486</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3N9U is a 4 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N9U OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n9/3n9u_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n9u ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Arrowsmith, C H.]]
[[Category: Large Structures]]
[[Category: Berg, S van der.]]
[[Category: Arrowsmith CH]]
[[Category: Berglund, H.]]
[[Category: Berglund H]]
[[Category: Bountra, C.]]
[[Category: Bountra C]]
[[Category: Collins, R.]]
[[Category: Collins R]]
[[Category: Edwards, A M.]]
[[Category: Edwards AM]]
[[Category: Flodin, S.]]
[[Category: Flodin S]]
[[Category: Flores, A.]]
[[Category: Flores A]]
[[Category: Graslund, S.]]
[[Category: Graslund S]]
[[Category: Hammarstrom, M.]]
[[Category: Hammarstrom M]]
[[Category: Johansson, I.]]
[[Category: Johansson I]]
[[Category: Karlberg, T.]]
[[Category: Karlberg T]]
[[Category: Kol, S.]]
[[Category: Kol S]]
[[Category: Kotenyova, T.]]
[[Category: Kotenyova T]]
[[Category: Moche, M.]]
[[Category: Moche M]]
[[Category: Nielsen, T N.]]
[[Category: Nielsen TN]]
[[Category: Nordlund, P.]]
[[Category: Nordlund P]]
[[Category: Nyman, T.]]
[[Category: Nyman T]]
[[Category: Persson, C.]]
[[Category: Persson C]]
[[Category: SGC, Structural Genomics Consortium.]]
[[Category: Schuler H]]
[[Category: Schuler, H.]]
[[Category: Schutz P]]
[[Category: Schutz, P.]]
[[Category: Siponen MI]]
[[Category: Siponen, M I.]]
[[Category: Thorsell AG]]
[[Category: Thorsell, A G.]]
[[Category: Tresaugues L]]
[[Category: Tresaugues, L.]]
[[Category: Wahlberg E]]
[[Category: Wahlberg, E.]]
[[Category: Weigelt J]]
[[Category: Weigelt, J.]]
[[Category: Welin M]]
[[Category: Welin, M.]]
[[Category: Wisniewska M]]
[[Category: Wisniewska, M.]]
[[Category: Van der Berg S]]
[[Category: Cleavage and polyadenylation specificity factor subunit 5]]
[[Category: Cleavage and polyadenylation specificity factor subunit 7]]
[[Category: Coexpression]]
[[Category: Cpsf5]]
[[Category: Cpsf7]]
[[Category: Heterotetramer]]
[[Category: Hydrolase]]
[[Category: Mrna cleavage]]
[[Category: Mrna maturation]]
[[Category: Nudix]]
[[Category: Nudt21]]
[[Category: Polyadenylation]]
[[Category: Pre-mrna cleavage factor im 25 kda subunit]]
[[Category: Pre-mrna cleavage factor im 59 kda subunit]]
[[Category: Protein-protein complex]]
[[Category: Rrm domain]]
[[Category: Sgc]]
[[Category: Sgc stockholm]]
[[Category: Splicing]]
[[Category: Structural genomic]]
[[Category: Structural genomics consortium]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jul 21 10:20:58 2010''
Retrieved from "https://proteopedia.org/3n9u"