2l0t: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l0t is ON HOLD until Paper Publication Authors: Lange, A., Hoeller, D., Wienk, H., Marcillat, O., Lancelin, J., Walker, O. Description: Solution s... |
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==Solution structure of the complex of ubiquitin and the VHS domain of Stam2== | |||
<StructureSection load='2l0t' size='340' side='right'caption='[[2l0t]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l0t]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L0T FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l0t OCA], [https://pdbe.org/2l0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l0t RCSB], [https://www.ebi.ac.uk/pdbsum/2l0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l0t ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). | |||
==See Also== | |||
*[[3D structures of ubiquitin|3D structures of ubiquitin]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hoeller D]] | |||
[[Category: Lancelin J]] | |||
[[Category: Lange A]] | |||
[[Category: Marcillat O]] | |||
[[Category: Walker O]] | |||
[[Category: Wienk H]] | |||
