Resolvase: Difference between revisions

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~~[[Image:~~1kcf~~.png|left|200px|thumb|Crystal structure of yeast~~ Holliday junction resolvase, [[1kcf]]]]

~~{{STRUCTURE_1kcf|~~ ~~PDB~~=~~1kcf~~ ~~| SIZE~~=~~300| SCENE~~= ~~|right|CAPTION~~=~~yeast Holliday junction resolvase,~~ [[~~1kcf~~]] }}

== Function ==

[[Resolvase]] or '''recombinase''' (Rec) is a nuclease which is involved in DNA recombination. According to the binding residue, the recombinases are grouped to Tyr- and Ser-recombinase.

*'''Holliday junction resolvase''' (HJR) resolves 4-way DNA intermediates known as Holliday junctions. Recombination of 2 DNA sites occurs when recombinase binds to the 2 strands<ref>PMID:19442245</ref>.

*'''Tyr-recombinases''' include '''Cre''' which recombines loxP sites, FLP and lambda integrase (LamInt).

*'''Ser-recombinases''' (S-rec) include gamma-delta resolvase (GDR), Tn3 resolvase and phiC31 integrase.

*'''RadA recombinase''' promotes DNA recombination. Detailed analysis of its <scene name='Resolvase/Cv/2'>dimeric structure</scene> suggests mechanisms for junction isomerization and communication between the two active sites <ref>PMID:19143611</ref>.

*'''RadB recombinase''' is a paralogue of RadA assisting in RadA-mediated strand exchange <ref>PMID:28501701</ref>.

*'''Hin-recombinase''' (HRec) is a protein of ''Salmonella''. HRec inverts a 900 base pair DNA segment which contains the promoters of flagellar genes. The inversion changes the these genes' expressions<ref>PMID:15454079</ref>.

*'''Tre recombinase''' recognizes a target sequence of the HIV virus resulting in excision and eradication of the provirus from infected human cells <ref>PMID:19066582</ref>.

==3D structures of resolvase==

[[Resolvase 3D structures]]

</StructureSection>

==References==

[[Category:Topic Page]]

Resolvase: Difference between revisions

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@@ Line 1: / Line 1: @@
-[[Image:1kcf.png|left|200px|thumb|Crystal structure of yeast Holliday junction resolvase, [[1kcf]]]]
+<StructureSection load='1kcf' size='340' side='right' caption='Yeast Holliday junction resolvase dimer complex with sulfate, [[1kcf]]' scene='' >
-{{STRUCTURE_1kcf|  PDB=1kcf  | SIZE=300| SCENE= |right|CAPTION=yeast Holliday junction resolvase, [[1kcf]] }}
+== Function ==
+[[Resolvase]] or '''recombinase''' (Rec) is a nuclease which is involved in DNA recombination. According to the binding residue, the recombinases are grouped to Tyr- and Ser-recombinase.
+*'''Holliday junction resolvase''' (HJR) resolves 4-way DNA intermediates known as Holliday junctions. Recombination of 2 DNA sites occurs when recombinase binds to the 2 strands<ref>PMID:19442245</ref>. <br />
+*'''Tyr-recombinases''' include '''Cre''' which recombines loxP sites, FLP and lambda integrase (LamInt). <br />
+*'''Ser-recombinases''' (S-rec) include gamma-delta resolvase  (GDR), Tn3 resolvase and phiC31 integrase.<br />
+*'''RadA recombinase''' promotes DNA recombination.  Detailed analysis of its <scene name='Resolvase/Cv/2'>dimeric structure</scene> suggests mechanisms for junction isomerization and communication between the two active sites <ref>PMID:19143611</ref>.  <br />
+*'''RadB recombinase''' is a paralogue of RadA assisting in RadA-mediated strand exchange <ref>PMID:28501701</ref>.  <br />
+*'''Hin-recombinase''' (HRec) is a protein of ''Salmonella''.  HRec inverts a 900 base pair DNA segment which contains the promoters of flagellar genes.  The inversion changes the these genes' expressions<ref>PMID:15454079</ref>.
+*'''Tre recombinase''' recognizes a target sequence of the HIV virus resulting in excision and eradication of the provirus from infected human cells <ref>PMID:19066582</ref>.  <br />
+==3D structures of resolvase==
+[[Resolvase 3D structures]]
+</StructureSection>
+==References==
+<references />
+[[Category:Topic Page]]