2rra: Difference between revisions
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==Solution structure of RNA binding domain in human Tra2 beta protein in complex with RNA (GAAGAA)== | |||
<StructureSection load='2rra' size='340' side='right'caption='[[2rra]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2rra]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RRA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RRA FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rra OCA], [https://pdbe.org/2rra PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rra RCSB], [https://www.ebi.ac.uk/pdbsum/2rra PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rra ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/TRA2B_HUMAN TRA2B_HUMAN] Sequence-specific RNA-binding protein which participates in the control of pre-mRNA splicing. Can either activate or suppress exon inclusion. Acts additively with RBMX to promote exon 7 inclusion of the survival motor neuron SMN2. Activates the splicing of MAPT/Tau exon 10. Alters pre-mRNA splicing patterns by antagonizing the effects of splicing regulators, like RBMX. Binds to the AG-rich SE2 domain in the SMN exon 7 RNA. Binds to pre-mRNA.<ref>PMID:9546399</ref> <ref>PMID:12165565</ref> <ref>PMID:12761049</ref> <ref>PMID:15009664</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Inoue M]] | |||
[[Category: Kigawa T]] | |||
[[Category: Kuwasako K]] | |||
[[Category: Muto Y]] | |||
[[Category: Shirouzu M]] | |||
[[Category: Someya T]] | |||
[[Category: Sugano S]] | |||
[[Category: Takahashi M]] | |||
[[Category: Terada T]] | |||
[[Category: Tsuda K]] | |||
[[Category: Yokoyama S]] | |||
Latest revision as of 07:06, 1 May 2024
Solution structure of RNA binding domain in human Tra2 beta protein in complex with RNA (GAAGAA)
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