3al6: Difference between revisions
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New page: '''Unreleased structure''' The entry 3al6 is ON HOLD Authors: Megumi Kato, Yuhei Araiso, Ryuichiro Ishitani, Osamu Nureki Description: Crystal structure of Human TYW5 ''Page seeded by... |
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==Crystal structure of Human TYW5== | |||
<StructureSection load='3al6' size='340' side='right'caption='[[3al6]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3al6]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3AL6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3AL6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AKG:2-OXOGLUTARIC+ACID'>AKG</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr> | |||
'' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3al6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3al6 OCA], [https://pdbe.org/3al6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3al6 RCSB], [https://www.ebi.ac.uk/pdbsum/3al6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3al6 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TYW5_HUMAN TYW5_HUMAN] tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a-amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes.<ref>PMID:20739293</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Araiso Y]] | |||
[[Category: Ishitani R]] | |||
[[Category: Kato M]] | |||
[[Category: Nureki O]] | |||
