2j5b: Difference between revisions

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[[Image:2j5b.jpg|left|200px]]<br /><applet load="2j5b" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2j5b, resolution 2.20&Aring;" />
'''STRUCTURE OF THE TYROSYL TRNA SYNTHETASE FROM ACANTHAMOEBA POLYPHAGA MIMIVIRUS COMPLEXED WITH TYROSYNOL'''<br />


==About this Structure==
==Structure of the Tyrosyl tRNA synthetase from Acanthamoeba polyphaga Mimivirus complexed with tyrosynol==
2J5B is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mimivirus Mimivirus] with TYB as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Tyrosine--tRNA_ligase Tyrosine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.1 6.1.1.1] Known structural/functional Site: <scene name='pdbsite=AC1:Tyb Binding Site For Chain B'>AC1</scene>. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2J5B OCA].
<StructureSection load='2j5b' size='340' side='right'caption='[[2j5b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
[[Category: Mimivirus]]
== Structural highlights ==
[[Category: Single protein]]
<table><tr><td colspan='2'>[[2j5b]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Acanthamoeba_polyphaga_mimivirus Acanthamoeba polyphaga mimivirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2J5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2J5B FirstGlance]. <br>
[[Category: Tyrosine--tRNA ligase]]
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
[[Category: Abergel, C.]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=TYE:4-[(2S)-2-AMINO-3-HYDROXYPROPYL]PHENOL'>TYE</scene></td></tr>
[[Category: Claverie, J.M.]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2j5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2j5b OCA], [https://pdbe.org/2j5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2j5b RCSB], [https://www.ebi.ac.uk/pdbsum/2j5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2j5b ProSAT]</span></td></tr>
[[Category: Giege, R.]]
</table>
[[Category: Rudinger-Thirion, J.]]
== Function ==
[[Category: TYB]]
[https://www.uniprot.org/uniprot/SYY_MIMIV SYY_MIMIV] Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity).<ref>PMID:15486256</ref> <ref>PMID:16510997</ref>
[[Category: ligase]]
== Evolutionary Conservation ==
[[Category: mimivirus]]
[[Image:Consurf_key_small.gif|200px|right]]
[[Category: tyrosyl trna synthetase]]
Check<jmol>
[[Category: tyrosynol]]
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/j5/2j5b_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2j5b ConSurf].
<div style="clear:both"></div>


''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Dec 18 19:49:35 2007''
==See Also==
*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Acanthamoeba polyphaga mimivirus]]
[[Category: Large Structures]]
[[Category: Abergel C]]
[[Category: Claverie JM]]
[[Category: Giege R]]
[[Category: Rudinger-thirion J]]
Retrieved from "https://proteopedia.org/2j5b"