2kzt: Difference between revisions

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'''Unreleased structure'''


The entry 2kzt is ON HOLD  until Paper Publication
==Structure of the Tandem MA-3 Region of Pdcd4==
<StructureSection load='2kzt' size='340' side='right'caption='[[2kzt]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2kzt]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KZT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KZT FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kzt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kzt OCA], [https://pdbe.org/2kzt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kzt RCSB], [https://www.ebi.ac.uk/pdbsum/2kzt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kzt ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PDCD4_HUMAN PDCD4_HUMAN] Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).<ref>PMID:16357133</ref> <ref>PMID:16449643</ref> <ref>PMID:17053147</ref> <ref>PMID:18296639</ref> <ref>PMID:19153607</ref> <ref>PMID:19204291</ref>


Authors: Waters, L.C., Strong, S.L., Oka, O., Muskett, F.W., Veverka, V., Banerjee, S., Schmedt, T., Henry, A.J., Klempnauer, K., Carr, M.D.
==See Also==
 
*[[Cell death protein 3D structures|Cell death protein 3D structures]]
Description: Structure of the Tandem MA-3 Region of Pdcd4
== References ==
 
<references/>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 18 11:15:05 2010''
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Banerjee S]]
[[Category: Carr MD]]
[[Category: Henry AJ]]
[[Category: Klempnauer KH]]
[[Category: Muskett FW]]
[[Category: Oka O]]
[[Category: Schmedt T]]
[[Category: Strong SL]]
[[Category: Veverka V]]
[[Category: Waters LC]]
Retrieved from "https://proteopedia.org/2kzt"