2z8m: Difference between revisions

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{{Seed}}
[[Image:2z8m.png|left|200px]]


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==Structural basis for the catalytic mechanism of phosphothreonine lyase==
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<StructureSection load='2z8m' size='340' side='right'caption='[[2z8m]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2z8m]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_Typhimurium Salmonella enterica subsp. enterica serovar Typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2Z8M FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2z8m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2z8m OCA], [https://pdbe.org/2z8m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2z8m RCSB], [https://www.ebi.ac.uk/pdbsum/2z8m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2z8m ProSAT]</span></td></tr>
{{STRUCTURE_2z8m|  PDB=2z8m  |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/SPVC_SALTY SPVC_SALTY] Secreted effector that irreversibly inactivates host MAP kinases by catalyzing the dephosphorylation of the phosphothreonine residue in the pT-X-pY motif in MAPK2/ERK2, MAPK3/ERK1, and p38, via a beta-elimination reaction leading to a dehydrobutyrine residue. Is also able to remove the phosphate group from phospho-JNK in vitro, but JNK may not be a substrate in vivo. Could help suppress localized proinflammatory responses at infection foci in the spleen and liver, and thereby facilitate bacterial growth.<ref>PMID:17303758</ref> <ref>PMID:18060821</ref> <ref>PMID:18084305</ref> <ref>PMID:18284579</ref>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Salmonella SpvC belongs to a new enzyme family designated phosphothreonine lyases that irreversibly inactivate mitogen-activated protein kinases. The crystal structure of SpvC reported here reveals that the two phosphorylated residues in the substrate peptide predominantly mediate its recognition by SpvC. Substrate-induced conformational changes in SpvC sequester the phosphothreonine in a completely solvent-free environment, preventing the hydrolysis of the phosphate group and facilitating the elimination reaction.


===Structural basis for the catalytic mechanism of phosphothreonine lyase===
Structural basis for the catalytic mechanism of phosphothreonine lyase.,Chen L, Wang H, Zhang J, Gu L, Huang N, Zhou JM, Chai J Nat Struct Mol Biol. 2008 Jan;15(1):101-2. Epub 2007 Dec 16. PMID:18084305<ref>PMID:18084305</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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<div class="pdbe-citations 2z8m" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 18084305 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_18084305}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Large Structures]]
2Z8M is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Salmonella_enterica_subsp._enterica_serovar_typhimurium Salmonella enterica subsp. enterica serovar typhimurium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2Z8M OCA].
[[Category: Salmonella enterica subsp. enterica serovar Typhimurium]]
 
[[Category: Chai J]]
==Reference==
[[Category: Chen L]]
<ref group="xtra">PMID:18084305</ref><references group="xtra"/>
[[Category: Gu L]]
[[Category: Salmonella enterica subsp. enterica serovar typhimurium]]
[[Category: Huang N]]
[[Category: Chai, J.]]
[[Category: Wang H]]
[[Category: Chen, L.]]
[[Category: Zhou JM]]
[[Category: Gu, L.]]
[[Category: Huang, N.]]
[[Category: Wang, H.]]
[[Category: Zhou, J M.]]
[[Category: Distorted beta-strand sheet]]
[[Category: Lyase]]
[[Category: Short three-helix bundle]]
[[Category: Virulence]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug 25 08:19:51 2010''
Retrieved from "https://proteopedia.org/2z8m"