3n6k: Difference between revisions

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{{Seed}}
[[Image:3n6k.png|left|200px]]


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==Human FPPS complex with NOV_823==
The line below this paragraph, containing "STRUCTURE_3n6k", creates the "Structure Box" on the page.
<StructureSection load='3n6k' size='340' side='right'caption='[[3n6k]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3n6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N6K FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.25&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BFH:1-(CARBOXYMETHYL)-1H-BENZO[G]INDOLE-2-CARBOXYLIC+ACID'>BFH</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
{{STRUCTURE_3n6k| PDB=3n6k |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n6k OCA], [https://pdbe.org/3n6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n6k RCSB], [https://www.ebi.ac.uk/pdbsum/3n6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n6k ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FPPS_HUMAN FPPS_HUMAN] Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n6/3n6k_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n6k ConSurf].
<div style="clear:both"></div>


===Human FPPS complex with NOV_823===
==See Also==
 
*[[Farnesyl diphosphate synthase 3D structures|Farnesyl diphosphate synthase 3D structures]]
 
__TOC__
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</StructureSection>
The line below this paragraph, {{ABSTRACT_PUBMED_20711197}}, adds the Publication Abstract to the page
(as it appears on PubMed at http://www.pubmed.gov), where 20711197 is the PubMed ID number.
-->
{{ABSTRACT_PUBMED_20711197}}
 
==About this Structure==
3N6K is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N6K OCA].
 
==Reference==
<ref group="xtra">PMID:20711197</ref><references group="xtra"/>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Rondeau, J M.]]
[[Category: Large Structures]]
[[Category: Bisphosphonate]]
[[Category: Rondeau J-M]]
[[Category: Cholesterol biosynthesis]]
[[Category: Fragment-based screening]]
[[Category: Isoprene biosynthesis]]
[[Category: Ransferase-transferase inhibitor complex]]
[[Category: Transferase]]
[[Category: Transferase-transferase inhibitor complex]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep  1 09:19:27 2010''
Retrieved from "https://proteopedia.org/3n6k"