2vac: Difference between revisions
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== | ==Structure of N-terminal Actin Depolymerizing Factor homology (ADF-H) domain of human twinfilin-2== | ||
<StructureSection load='2vac' size='340' side='right'caption='[[2vac]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2vac]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VAC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VAC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vac FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vac OCA], [https://pdbe.org/2vac PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vac RCSB], [https://www.ebi.ac.uk/pdbsum/2vac PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vac ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/TWF2_HUMAN TWF2_HUMAN] Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity). | |||
== Evolutionary Conservation == | |||
[[Image:Consurf_key_small.gif|200px|right]] | |||
Check<jmol> | |||
<jmolCheckbox> | |||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/va/2vac_consurf.spt"</scriptWhenChecked> | |||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | |||
<text>to colour the structure by Evolutionary Conservation</text> | |||
</jmolCheckbox> | |||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vac ConSurf]. | |||
<div style="clear:both"></div> | |||
==See Also== | |||
*[[Twinfilin|Twinfilin]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Elkins JM]] | ||
[[Category: Elkins | [[Category: King O]] | ||
[[Category: King | [[Category: Knapp S]] | ||
[[Category: Knapp | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Salah E]] | ||
[[Category: Salah | [[Category: Savitsky P]] | ||
[[Category: Savitsky | [[Category: Sundstrom M]] | ||
[[Category: Sundstrom | [[Category: Weigelt J]] | ||
[[Category: Weigelt | [[Category: Von Delft F]] | ||
[[Category: | |||
Latest revision as of 15:12, 13 December 2023
Structure of N-terminal Actin Depolymerizing Factor homology (ADF-H) domain of human twinfilin-2
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