3mxn: Difference between revisions

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{{Seed}}
[[Image:3mxn.jpg|left|200px]]


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==Crystal structure of the RMI core complex==
The line below this paragraph, containing "STRUCTURE_3mxn", creates the "Structure Box" on the page.
<StructureSection load='3mxn' size='340' side='right'caption='[[3mxn]], [[Resolution|resolution]] 1.55&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3mxn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MXN FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BEN:BENZAMIDINE'>BEN</scene></td></tr>
{{STRUCTURE_3mxn|  PDB=3mxn  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3mxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3mxn OCA], [https://pdbe.org/3mxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3mxn RCSB], [https://www.ebi.ac.uk/pdbsum/3mxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3mxn ProSAT]</span></td></tr>
 
</table>
===Crystal structure of the RMI core complex===
== Function ==
 
[https://www.uniprot.org/uniprot/RMI1_HUMAN RMI1_HUMAN] Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.<ref>PMID:15775963</ref> <ref>PMID:16595695</ref> <ref>PMID:16537486</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
3MXN is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MXN OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/mx/3mxn_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3mxn ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Hoadley, K A.]]
[[Category: Large Structures]]
[[Category: Keck, J L.]]
[[Category: Hoadley KA]]
[[Category: Satyshur, K A.]]
[[Category: Keck JL]]
[[Category: Wang, W.]]
[[Category: Satyshur KA]]
[[Category: Xu, D.]]
[[Category: Wang W]]
[[Category: Xue, Y.]]
[[Category: Xu D]]
[[Category: Bloom syndrome]]
[[Category: Xue Y]]
[[Category: Helicase]]
[[Category: Replication]]
[[Category: Replication protein some]]
[[Category: Rmi]]
[[Category: Topoisomerase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:50:28 2010''
Retrieved from "https://proteopedia.org/3mxn"