3nti: Difference between revisions

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{{Seed}}
[[Image:3nti.jpg|left|200px]]


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==Crystal structure of Tudor and Aubergine [R15(me2s)] complex==
The line below this paragraph, containing "STRUCTURE_3nti", creates the "Structure Box" on the page.
<StructureSection load='3nti' size='340' side='right'caption='[[3nti]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3nti]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NTI FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2MR:N3,+N4-DIMETHYLARGININE'>2MR</scene></td></tr>
{{STRUCTURE_3nti|  PDB=3nti  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nti FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nti OCA], [https://pdbe.org/3nti PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nti RCSB], [https://www.ebi.ac.uk/pdbsum/3nti PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nti ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TUD_DROME TUD_DROME] Required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nt/3nti_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3nti ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Piwi proteins are modified by symmetric dimethylation of arginine (sDMA), and the methylarginine-dependent interaction with Tudor domain proteins is critical for their functions in germline development. Cocrystal structures of an extended Tudor domain (eTud) of Drosophila Tudor with methylated peptides of Aubergine, a Piwi family protein, reveal that sDMA is recognized by an asparagine-gated aromatic cage. Furthermore, the unexpected Tudor-SN/p100 fold of eTud is important for sensing the position of sDMA. The structural information provides mechanistic insights into sDMA-dependent Piwi-Tudor interaction, and the recognition of sDMA by Tudor domains in general.


===Crystal structure of Tudor and Aubergine [R15(me2s)] complex===
Structural basis for methylarginine-dependent recognition of Aubergine by Tudor.,Liu H, Wang JY, Huang Y, Li Z, Gong W, Lehmann R, Xu RM Genes Dev. 2010 Sep 1;24(17):1876-81. Epub 2010 Aug 16. PMID:20713507<ref>PMID:20713507</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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The line below this paragraph, {{ABSTRACT_PUBMED_20713507}}, adds the Publication Abstract to the page
<div class="pdbe-citations 3nti" style="background-color:#fffaf0;"></div>
(as it appears on PubMed at http://www.pubmed.gov), where 20713507 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_20713507}}
__TOC__
 
</StructureSection>
==About this Structure==
3NTI is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NTI OCA].
 
==Reference==
<ref group="xtra">PMID:20713507</ref><references group="xtra"/>
[[Category: Drosophila melanogaster]]
[[Category: Drosophila melanogaster]]
[[Category: Gong, W M.]]
[[Category: Large Structures]]
[[Category: Huang, Y.]]
[[Category: Gong WM]]
[[Category: Li, Z Z.]]
[[Category: Huang Y]]
[[Category: Liu, H P.]]
[[Category: Li ZZ]]
[[Category: Xu, R M.]]
[[Category: Liu HP]]
[[Category: Germ cell formation]]
[[Category: Xu RM]]
[[Category: Ob-fold]]
[[Category: Transcription]]
[[Category: Tudor domain]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 15 10:52:44 2010''

Latest revision as of 16:51, 1 November 2023

Crystal structure of Tudor and Aubergine [R15(me2s)] complex

3nti, resolution 2.80Å

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