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| [[Image:1ya5.png|left|200px|thumb|Crystal structure of telethonin in complex with titin domains z1z2, [[1ya5]]]]
| | <StructureSection load='' size='350' side='right' scene='Telethonin/Cv/1' caption='Crystal structure of telethonin (dark green) in complex with titin domains z1z2 dimer (grey and light green) and sulfate (PDB code [[1ya5]])'> |
| {{STRUCTURE_1ya5| PDB=1ya5 | SIZE=300| SCENE=Telethonin/Cv/1 |right|CAPTION=Crystal structure of telethonin in complex with titin domains z1z2, [[1ya5]] }}
| | == Function == |
| | | [[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly<ref>PMID:11699871</ref>. It is called [[titin]] cap protein. See also [[Group:MUZIC:Telethonin]]. |
| [[Telethonin]] is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly. It is called [[titin]] cap protein. The images at the left and at the right correspond to one representative RecA, ''i.e.'' the crystal structure of <scene name='Telethonin/Cv/2'>telethonin</scene> in complex with titin domains z1z2 ([[1ya5]]). | |
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| | == Disease == |
| | Mutations in telethonin lead to heart maladptation to biomechanical stress<ref>PMID:21799151</ref>. |
| | </StructureSection> |
| == 3D Structures of Telethonin == | | == 3D Structures of Telethonin == |
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| [[2f8v]], [[1ya5]] - telethonin+ hTTN residues 1-196 - human | | [[2f8v]], [[1ya5]] - telethonin+ hTTN residues 1-196 - human |
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| | == References == |
| | <references/> |
| | [[Category:Topic Page]] |
Latest revision as of 12:13, 9 October 2017
| Function
Telethonin is found in muscle cells and binds titin Z1-Z2 domains. It is essential to sarcomer assembly[1]. It is called titin cap protein. See also Group:MUZIC:Telethonin.
Disease
Mutations in telethonin lead to heart maladptation to biomechanical stress[2].
- ↑ Faulkner G, Lanfranchi G, Valle G. Telethonin and other new proteins of the Z-disc of skeletal muscle. IUBMB Life. 2001 May;51(5):275-82. PMID:11699871 doi:10.1080/152165401317190761
- ↑ Knoll R, Linke WA, Zou P, Miocic S, Kostin S, Buyandelger B, Ku CH, Neef S, Bug M, Schafer K, Knoll G, Felkin LE, Wessels J, Toischer K, Hagn F, Kessler H, Didie M, Quentin T, Maier LS, Teucher N, Unsold B, Schmidt A, Birks EJ, Gunkel S, Lang P, Granzier H, Zimmermann WH, Field LJ, Faulkner G, Dobbelstein M, Barton PJ, Sattler M, Wilmanns M, Chien KR. Telethonin deficiency is associated with maladaptation to biomechanical stress in the mammalian heart. Circ Res. 2011 Sep 16;109(7):758-69. doi: 10.1161/CIRCRESAHA.111.245787. Epub, 2011 Jul 28. PMID:21799151 doi:https://dx.doi.org/10.1161/CIRCRESAHA.111.245787
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3D Structures of Telethonin
titin, 1ya5 - telethonin+ hTTN residues 1-196 - human
References
