TATA-Binding Protein: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
No edit summary
Michal Harel (talk | contribs)
32,850 edits
No edit summary
 
(34 intermediate revisions by 3 users not shown)
Line 1: Line 1:
[[Image:1tbp.png|left|200px|thumb|Crystal Structure of yeast TATA-binding protein, [[1tbp]]]]
<StructureSection load='1tgh' size='350' side='right' scene='' caption='Human TATA-binding protein complex with DNA TATA box (PDB code [[1tgh]])'>
{{STRUCTURE_1tbp| PDB=1tbp | SIZE=300| SCENE=TATA-Binding_Protein/Cv/1 |right|CAPTION=TATA-binding protein, [[1tbp]] }}
== Function ==
[[TATA-Binding Protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex.  The transcription factor proteins are named TFIIA to TFIIH. TBP is part of TFIID. Its interaction with DNA initiates the DNA strands separation<ref>PMID:7565278</ref>.  Called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif.  See also<br />
* [[Transcription and RNA Processing]]<br />
* [[Yeast TATA Binding Protein]].


[[TATA-binding protein]] (TBP) binds to TATA box in DNA and is part of the RNA polymerase II transcription complex.  The transcription factor proteins are named TFIIA to TFIIH.  TBP is part of TFIID.  Its interaction with DNA initiates the DNA strands separation. The images at the left and at the right correspond to one representative TBP, ''i.e.'' the crystal structure of yeast TATA-binding protein ([[1tbp]]).
== Additional information ==
 
{{TOC limit|limit=2}}
 
== 3D Structures of TATA-binding protein ==
 
 
 
=== TBP ===


See: [[Transcription]] for additional Proteopedia resources


2z8u – TBP – Methanococcus janaschii
== Relevance ==
1pcz – PwTBP - Pyrococcus woesei
TBP is associated with aggregated proteins in several of the polyglutamine disorders like cerebellar ataxia<ref>PMID:15916858</ref>.
1vok – AtTBP - Arabidopsis thaliana
1tbp – yTBP - yeast
1mp9 – TBP – Sulfolobus acidocaldarius


 
== Structural highlights ==
=== TBP+DNA TATA ===
 
 
1ytb - yTBP + DNA TATA
1cdw - hTBP core domain+ DNA TATA - human
1tgh - hTBP + DNA TATA
1qn5, 1qn6, 1qn7, 1qn8, 1qn9, 1qna, 1qnb, 1qnc, 1qne, 1qn3, 1qn4 - AtTBP + DNA TATA
 
 
=== TBP+DNA TATA+TFIIA ===
 
 
1rm1 – yTBP+TFIIA chains+ DNA TATA
1ytf - yTBP+TFIIA + DNA TATA
1nh2 – yTBP C-terminal+TFIIA chains+ DNA TATA
1nvp - hTBP C-terminal+ TFIIA  chains+ DNA TATA
1jfi - hTBP C-terminal+ TFIIA C2+ DNA TATA
 
 
=== TBP+DNA TATA+TFIIB ===
 
 
1ngm - yTBP C-terminal+TFIIIB BRF1 subunit + DNA TATA
1tba – yTBP core domain+TAFII230 fragment - NMR
1c9b - hTBP C-terminal+TFIIBC+adenovirus major late promoter
1vol – AtTBP+hTFIIB+DNA TATA
1ais, 1du3 - PwTBP N-terminal+ TFIIB C-terminal + DNA TATA
 
1tba – yTBP core domain+TAFII230 fragment - NMR
 
 
== Additional information ==
 
This page has some initial scenes, but could use expansion and creation of new scenes.
<applet load='1ytb' size='300' frame='true' align='right' caption='TATA-Binding Protein' scene='TATA-Binding_Protein/Tata-binding-protein/5' />
 
called the <scene name='TATA-Binding_Protein/Tata_box/3'> TATA box</scene> to represent its thymine-adenine-thymine-adenine-adenine (TATAA) nucleotide motif


<scene name='TATA-Binding_Protein/Lysine_and_arginine_phosphate/1'>interact with the phosphate groups</scene>
<scene name='TATA-Binding_Protein/Lysine_and_arginine_phosphate/1'>interact with the phosphate groups</scene>
Line 65: Line 21:


<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.  
<scene name='TATA-Binding_Protein/Symmetrical/5'>two symmetrical halves</scene>.  
The interactions of <scene name='10/100866/Cv/2'>TBP with the DNA TATA box occurs with the minor groove of the DNA</scene>.  The DNA duplex is bent in a sharp angle and most interactions are non-polar of hydrophobic<ref>PMID:8757291</ref>.


{{Clear}}
{{Clear}}
== 3D Structures of TATA-binding protein ==
[[TATA-binding protein 3D structures]]
</StructureSection>
== References ==
<references/>
[[Category:Topic Page]]
Retrieved from "https://proteopedia.org/TATA-Binding_Protein"