2qud: Difference between revisions

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New page: left|200px<br /><applet load="2qud" size="350" color="white" frame="true" align="right" spinBox="true" caption="2qud, resolution 1.60Å" /> '''PP7 Coat Protein Dim...
 
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[[Image:2qud.jpg|left|200px]]<br /><applet load="2qud" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2qud, resolution 1.60&Aring;" />
'''PP7 Coat Protein Dimer'''<br />


==Overview==
==PP7 Coat Protein Dimer==
The cocrystal structure of the PP7 bacteriophage coat protein in complex, with its translational operator identifies a distinct mode of, sequence-specific RNA recognition when compared to the well-characterized, MS2 coat protein-RNA complex. The structure reveals the molecular basis of, the PP7 coat protein's ability to selectively bind its cognate RNA, and it, demonstrates that the conserved beta-sheet surface is a flexible, architecture that can evolve to recognize diverse RNA hairpins.
<StructureSection load='2qud' size='340' side='right'caption='[[2qud]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2qud]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_phage_PP7 Pseudomonas phage PP7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QUD FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.6&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qud FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qud OCA], [https://pdbe.org/2qud PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qud RCSB], [https://www.ebi.ac.uk/pdbsum/2qud PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qud ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/Q38062_BPPP7 Q38062_BPPP7]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The cocrystal structure of the PP7 bacteriophage coat protein in complex with its translational operator identifies a distinct mode of sequence-specific RNA recognition when compared to the well-characterized MS2 coat protein-RNA complex. The structure reveals the molecular basis of the PP7 coat protein's ability to selectively bind its cognate RNA, and it demonstrates that the conserved beta-sheet surface is a flexible architecture that can evolve to recognize diverse RNA hairpins.


==About this Structure==
Structural basis for the coevolution of a viral RNA-protein complex.,Chao JA, Patskovsky Y, Almo SC, Singer RH Nat Struct Mol Biol. 2008 Jan;15(1):103-5. Epub 2007 Dec 9. PMID:18066080<ref>PMID:18066080</ref>
2QUD is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_p21 Enterobacteria phage p21] with <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QUD OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Structural basis for the coevolution of a viral RNA-protein complex., Chao JA, Patskovsky Y, Almo SC, Singer RH, Nat Struct Mol Biol. 2008 Jan;15(1):103-5. Epub 2007 Dec 9. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18066080 18066080]
</div>
[[Category: Enterobacteria phage p21]]
<div class="pdbe-citations 2qud" style="background-color:#fffaf0;"></div>
[[Category: Single protein]]
== References ==
[[Category: Chao, J.A.]]
<references/>
[[Category: GOL]]
__TOC__
[[Category: bacteriophage]]
</StructureSection>
[[Category: capsid protein]]
[[Category: Large Structures]]
[[Category: rna binding protein]]
[[Category: Pseudomonas phage PP7]]
[[Category: rna-protein complex]]
[[Category: Chao JA]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Jan 23 10:44:04 2008''

Latest revision as of 11:40, 30 August 2023

PP7 Coat Protein Dimer

2qud, resolution 1.60Å

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