RNA Interference: Difference between revisions

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{{Structure
{{Structure
|PDB= 3dlh |SIZE=400|SCENE=RNA_Interference/3dlh/1|CAPTION=  guide-strand-containing Argonaute protein silencing complex [[3dlh]], resolution 3.00&Aring; (<scene name='RNA_Interference/3dlh/1'>initial scene</scene>)
|PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION=  guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00&Aring; (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>)
|SITE=  
|SITE=  
|LIGAND=
|LIGAND=
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}}
}}
[[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.  
[[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.  
 
[[Image:500px-ShRNA Lentivirus.png|350px|left|thumb| Schematic of RNAi Interference in Mammalian Cells]]
[[Image:500px-ShRNA Lentivirus.png|350px|right|thumb| Schematic of RNAi Interference in Mammalian Cells]]
 
{{Structure
{{Structure
|PDB= 1rpu |SIZE=400|ALIGN=Left|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50&Aring; (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>)
|PDB= 1rpu |SIZE=300|ALIGN='left'|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA ([[1rpu]]), resolution 2.50&Aring; (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>)
|SITE=  
|SITE=  
|LIGAND=
|LIGAND=
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|RESOURCES=<span class='plainlinks'><!--[http://www-unix.oit.umass.edu/~wdecatur/p19tutorial/ Explorable Tour], Eric Martz felt no one would look here-->[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpu OCA], [http://www.ebi.ac.uk/pdbsum/1rpu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rpu RCSB]</span>
|RESOURCES=<span class='plainlinks'><!--[http://www-unix.oit.umass.edu/~wdecatur/p19tutorial/ Explorable Tour], Eric Martz felt no one would look here-->[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpu OCA], [http://www.ebi.ac.uk/pdbsum/1rpu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rpu RCSB]</span>
}}
}}
Articles in Proteopedia concerning RNA Interference include:


Articles in Proteopedia concerning RNA Interference include:
**[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
**[[Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing|Plant Viral Protein p19 Supression of RNA Silencing]]
**[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
**[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
 
 
See RNAi in action by viewing this
[http://www.nature.com/nrg/multimedia/rnai/index.html RNAi Animation].


*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
*[[Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing|Plant Viral Protein p19 Supression of RNA Silencing]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
<br />


To view automatically seeded pages concerning RNA Interference See:
To view automatically seeded indices concerning RNA Interference, see:
*[[:Category:Rnai|RNAi]]
**[[:Category:Argonaute|Argonaute]]
*[[:Category:Rnai_suppression|RNAi Suppression]]
**[[:Category:Dicer|Dicer]]
*[[:Category:Rna interference|RNA Interference]]
**[[:Category:Drosha|Drosha]]
*[[:Category:Risc|RISC]]
**[[:Category:Piwi|Piwi]]
*[[:Category:Dicer|Dicer]]
**[[:Category:Risc|RISC]]
*[[:Category:Argonaute|Argonaute]]
**[[:Category:Rnai|RNAi]]
*[[:Category:Slicer|Slicer]]
**[[:Category:Rnai_suppression|RNAi Suppression]]
*[[:Category:Piwi|Piwi]]
**[[:Category:Rna interference|RNA Interference]]
**[[:Category:Slicer|Slicer]]
<br />
<br />


To view other Proteopedia pages about diseases & drug targets, See: [[Pharmaceutical_Drug_Targets|Pharmaceutical Drug Targets]]
To view other Proteopedia pages about diseases & drug targets, see: [[Pharmaceutical_Drug_Targets|Pharmaceutical Drug Targets]]

Latest revision as of 18:42, 26 March 2012

Drag the structure with the mouse to rotate
guide-strand-containing Argonaute protein silencing complex (3dlh), resolution 3.00Å (initial scene)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


RNA Interference (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded RNA is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.

Schematic of RNAi Interference in Mammalian Cells
Drag the structure with the mouse to rotate
viral silencing suppressor bound to a siRNA (1rpu), resolution 2.50Å (initial scene)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml


Articles in Proteopedia concerning RNA Interference include:


See RNAi in action by viewing this RNAi Animation.


To view automatically seeded indices concerning RNA Interference, see:


To view other Proteopedia pages about diseases & drug targets, see: Pharmaceutical Drug Targets

Proteopedia Page Contributors and Editors (what is this?)

David Canner, Wayne Decatur, Eric Martz

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