2p3s: Difference between revisions

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New page: left|200px<br /><applet load="2p3s" size="350" color="white" frame="true" align="right" spinBox="true" caption="2p3s, resolution 1.800Å" /> '''Crystal structure o...
 
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[[Image:2p3s.jpg|left|200px]]<br /><applet load="2p3s" size="350" color="white" frame="true" align="right" spinBox="true"
caption="2p3s, resolution 1.800&Aring;" />
'''Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (G214R/Q199R)'''<br />


==About this Structure==
==Crystal structure of a thermostable mutant of Bacillus subtilis Adenylate Kinase (G214R/Q199R)==
2P3S is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=MG:'>MG</scene> and <scene name='pdbligand=AP5:'>AP5</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Adenylate_kinase Adenylate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.3 2.7.4.3] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3S OCA].  
<StructureSection load='2p3s' size='340' side='right'caption='[[2p3s]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
[[Category: Adenylate kinase]]
== Structural highlights ==
<table><tr><td colspan='2'>[[2p3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2P3S FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AP5:BIS(ADENOSINE)-5-PENTAPHOSPHATE'>AP5</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2p3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p3s OCA], [https://pdbe.org/2p3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2p3s RCSB], [https://www.ebi.ac.uk/pdbsum/2p3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2p3s ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/KAD_BACSU KAD_BACSU] Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. This small ubiquitous enzyme involved in the energy metabolism and nucleotide synthesis, is essential for maintenance and cell growth.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/p3/2p3s_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2p3s ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[Adenylate kinase 3D structures|Adenylate kinase 3D structures]]
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Counago, R.]]
[[Category: Counago R]]
[[Category: Myers, J.]]
[[Category: Myers J]]
[[Category: Shamoo, Y.]]
[[Category: Shamoo Y]]
[[Category: Wilson, C.J.]]
[[Category: Wilson CJ]]
[[Category: Wu, G.]]
[[Category: Wu G]]
[[Category: AP5]]
[[Category: MG]]
[[Category: ZN]]
[[Category: adenylate kinase]]
[[Category: directed evolution]]
[[Category: experimental adaptive evolution]]
[[Category: thermostability]]
[[Category: transferase]]
 
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Retrieved from "https://proteopedia.org/2p3s"