RNA Interference: Difference between revisions

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[[Image:500px-ShRNA Lentivirus.png|350px|left|thumb| Schematic of RNAi Interference in Mammalian Cells]]
[[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.
{{Structure
{{Structure
|PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION=  guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00&Aring; (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>)
|PDB= 3dlh |SIZE=300|SCENE=RNA_Interference/3dlh/2|CAPTION=  guide-strand-containing Argonaute protein silencing complex ([[3dlh]]), resolution 3.00&Aring; (<scene name='RNA_Interference/3dlh/2'>initial scene</scene>)
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlh OCA], [http://www.ebi.ac.uk/pdbsum/3dlh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3dlh RCSB]</span>
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3dlh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3dlh OCA], [http://www.ebi.ac.uk/pdbsum/3dlh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=3dlh RCSB]</span>
}}
}}
[[RNA Interference]] (RNAi) is a system in living cells that helps control the level of activity of genes. In RNAi, a long double stranded [[RNA]] is cleaved into shorter strands. One strand known as the guide strand is complimentary to the mRNA gene product of a gene of interest. This guide strand is incorporated into an RNA-induced silencing complex (RISC) and subsequently binds the mRNA of the gene of interest. After binding, the RNA/RISC complex subsequently silences the mRNA of interest via cleavage of the mRNA strand.
[[Image:500px-ShRNA Lentivirus.png|350px|left|thumb| Schematic of RNAi Interference in Mammalian Cells]]
{{Structure
{{Structure
|PDB= 1rpu |SIZE=300|ALIGN='left'|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA ([[1rpu]]), resolution 2.50&Aring; (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>)
|PDB= 1rpu |SIZE=300|ALIGN='left'|SCENE=User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2|CAPTION= viral silencing suppressor bound to a siRNA ([[1rpu]]), resolution 2.50&Aring; (<scene name='User:Wayne_Decatur/Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing/View1/2'>initial scene</scene>)
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Articles in Proteopedia concerning RNA Interference include:
Articles in Proteopedia concerning RNA Interference include:


*[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
**[[Suppression of RNA Silencing by Viruses|Suppression of RNA Silencing by Viruses]]
*[[Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing|Plant Viral Protein p19 Supression of RNA Silencing]]
**[[Plant_Viral_Protein_p19_Suppression_of_RNA_Silencing|Plant Viral Protein p19 Supression of RNA Silencing]]
*[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
**[[Tomato aspermy virus protein 2b Suppression of RNA Silencing|Tomato aspermy virus protein 2b Suppression of RNA Silencing]]
*[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
**[[Flock house virus B2 protein Suppression of RNA Silencing|Flock house virus B2 protein Suppression of RNA Silencing]]
<br />
 
 
See RNAi in action by viewing this
[http://www.nature.com/nrg/multimedia/rnai/index.html RNAi Animation].
 


To view automatically seeded indices concerning RNA Interference See:
To view automatically seeded indices concerning RNA Interference, see:
*[[:Category:Argonaute|Argonaute]]
**[[:Category:Argonaute|Argonaute]]
*[[:Category:Dicer|Dicer]]
**[[:Category:Dicer|Dicer]]
*[[:Category:Drosha|Drosha]]
**[[:Category:Drosha|Drosha]]
*[[:Category:Piwi|Piwi]]
**[[:Category:Piwi|Piwi]]
*[[:Category:Risc|RISC]]
**[[:Category:Risc|RISC]]
*[[:Category:Rnai|RNAi]]
**[[:Category:Rnai|RNAi]]
*[[:Category:Rnai_suppression|RNAi Suppression]]
**[[:Category:Rnai_suppression|RNAi Suppression]]
*[[:Category:Rna interference|RNA Interference]]
**[[:Category:Rna interference|RNA Interference]]
*[[:Category:Slicer|Slicer]]
**[[:Category:Slicer|Slicer]]
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To view other Proteopedia pages about diseases & drug targets, See: [[Pharmaceutical_Drug_Targets|Pharmaceutical Drug Targets]]
To view other Proteopedia pages about diseases & drug targets, see: [[Pharmaceutical_Drug_Targets|Pharmaceutical Drug Targets]]
Retrieved from "https://proteopedia.org/RNA_Interference"