3i8p: Difference between revisions

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{{Seed}}
[[Image:3i8p.png|left|200px]]


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==Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1==
The line below this paragraph, containing "STRUCTURE_3i8p", creates the "Structure Box" on the page.
<StructureSection load='3i8p' size='340' side='right'caption='[[3i8p]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3i8p]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_K-12 Escherichia coli K-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3I8P FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=840:PLATENSIMYCIN+A1'>840</scene></td></tr>
{{STRUCTURE_3i8p|  PDB=3i8p  |  SCENE=  }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3i8p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3i8p OCA], [https://pdbe.org/3i8p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3i8p RCSB], [https://www.ebi.ac.uk/pdbsum/3i8p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3i8p ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/FABF_ECOLI FABF_ECOLI] Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i8/3i8p_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3i8p ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Natural products continue to serve as one of the best sources for discovery of antibacterial agents as exemplified by the recent discoveries of platensimycin and platencin. Chemical modifications as well as discovery of congeners are the main sources for gaining knowledge of structure-activity relationship of natural products. Screening for congeners in the extracts of the fermentation broths of Streptomyces platensis led to the isolation of platencin A(1), a hydroxy congener of platencin. The hydroxylation of the tricyclic enone moiety negatively affected the antibacterial activity and appears to be consistent with the hydrophobic binding pocket of the FabF. Isolation, structure, enzyme-bound structure and activity of platencin A(1) and two other congeners have been described.


===Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1===
Isolation, enzyme-bound structure and antibacterial activity of platencin A1 from Streptomyces platensis.,Singh SB, Ondeyka JG, Herath KB, Zhang C, Jayasuriya H, Zink DL, Parthasarathy G, Becker JW, Wang J, Soisson SM Bioorg Med Chem Lett. 2009 Aug 15;19(16):4756-9. Epub 2009 Jun 17. PMID:19581087<ref>PMID:19581087</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3i8p" style="background-color:#fffaf0;"></div>


<!--
==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_19581087}}, adds the Publication Abstract to the page
*[[Acyl carrier protein synthase 3D structures|Acyl carrier protein synthase 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 19581087 is the PubMed ID number.
== References ==
-->
<references/>
{{ABSTRACT_PUBMED_19581087}}
__TOC__
 
</StructureSection>
==About this Structure==
[[Category: Escherichia coli K-12]]
3I8P is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli_k-12 Escherichia coli k-12]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3I8P OCA].
[[Category: Large Structures]]
 
[[Category: Parthsarathy G]]
==Reference==
[[Category: Soisson SM]]
<ref group="xtra">PMID:19581087</ref><references group="xtra"/>
[[Category: Beta-ketoacyl-acyl-carrier-protein synthase II]]
[[Category: Escherichia coli k-12]]
[[Category: Parthsarathy, G.]]
[[Category: Soisson, S M.]]
[[Category: Acyltransferase]]
[[Category: Fabf]]
[[Category: Fatty acid biosynthesis]]
[[Category: Kasii]]
[[Category: Lipid synthesis]]
[[Category: Platensimycin]]
[[Category: Platensimycin a1]]
[[Category: Transferase]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:41:43 2010''

Latest revision as of 07:40, 6 September 2023

Crystal structure of E. coli FabF(C163A) in complex with Platensimycin A1

3i8p, resolution 1.90Å

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