3oq9: Difference between revisions

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'''Unreleased structure'''


The entry 3oq9 is ON HOLD  until Paper Publication
==Structure of the FAS/FADD death domain assembly==
<StructureSection load='3oq9' size='340' side='right'caption='[[3oq9]], [[Resolution|resolution]] 6.80&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[3oq9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OQ9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OQ9 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 6.8&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oq9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oq9 OCA], [https://pdbe.org/3oq9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oq9 RCSB], [https://www.ebi.ac.uk/pdbsum/3oq9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oq9 ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE] Note=Defects in Fas are the cause of the lymphoproliferation phenotype (lpr). Lpr mice show lymphadenopathy and autoantibody production.
== Function ==
[https://www.uniprot.org/uniprot/TNR6_MOUSE TNR6_MOUSE] Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both (By similarity).


Authors: Kabaleeswaran, V., Wu, H.
==See Also==
 
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]]
Description: Structure of the FAS/FADD death domain assembly
__TOC__
 
</StructureSection>
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Sep 29 07:56:52 2010''
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Kabaleeswaran V]]
[[Category: Wu H]]
Retrieved from "https://proteopedia.org/3oq9"