3ozb: Difference between revisions
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New page: '''Unreleased structure''' The entry 3ozb is ON HOLD Authors: Ho, M., Guan, R., Almo, S.C., Schramm, V.L. Description: Crystal Structure of 5'-methylthioinosine phosphorylase from Psed... |
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==Crystal Structure of 5'-methylthioinosine phosphorylase from Psedomonas aeruginosa in complex with hypoxanthine== | |||
<StructureSection load='3ozb' size='340' side='right'caption='[[3ozb]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3ozb]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OZB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OZB FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HPA:HYPOXANTHINE'>HPA</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
'' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ozb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ozb OCA], [https://pdbe.org/3ozb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ozb RCSB], [https://www.ebi.ac.uk/pdbsum/3ozb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ozb ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MTIP_PSEAE MTIP_PSEAE] Catalyzes the reversible phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine and 5-methylthioribose-1-phosphate. Involved in the breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis. Catabolism of (MTA) occurs via deamination to MTI and phosphorolysis to hypoxanthine. Involved in quorum sensing.[HAMAP-Rule:MF_01963]<ref>PMID:21197954</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa PAO1]] | |||
[[Category: Almo SC]] | |||
[[Category: Guan R]] | |||
[[Category: Ho M]] | |||
[[Category: Schramm VL]] | |||
Latest revision as of 10:37, 21 February 2024
Crystal Structure of 5'-methylthioinosine phosphorylase from Psedomonas aeruginosa in complex with hypoxanthine
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