2l4h: Difference between revisions
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New page: '''Unreleased structure''' The entry 2l4h is ON HOLD Authors: Huang, H., Vogel, H.J. Description: The Solution Structure of Calcium Bound CIB1 ''Page seeded by [http://oca.weizmann.ac... |
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The | ==The Solution Structure of Calcium Bound CIB1== | ||
<StructureSection load='2l4h' size='340' side='right'caption='[[2l4h]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l4h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L4H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L4H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr> | |||
'' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l4h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l4h OCA], [https://pdbe.org/2l4h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l4h RCSB], [https://www.ebi.ac.uk/pdbsum/2l4h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l4h ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/CIB1_HUMAN CIB1_HUMAN] May convert the inactive conformation of integrin alpha-IIb/beta3 to an active form through binding to the integrin cytoplasmic domain. Induces cell migration and spreading mediated through integrin (possibly via focal adhesion complexes). Functions as a negative regulator of stress activated MAP kinase (MAPK) signaling pathways. May play a role in regulation of apoptosis. Interacts with and up-regulates PTK2/FAK1 activity. Down regulates inositol 1,4,5-trisphosphate receptor-dependent calcium signaling. Participates in endomitotic cell cycle, a form of mitosis in which both karyokinesis and cytokinesis are interrupted and is a hallmark of megakaryocyte differentiation.<ref>PMID:12714504</ref> <ref>PMID:12881299</ref> <ref>PMID:15685448</ref> <ref>PMID:18627437</ref> <ref>PMID:19805025</ref> <ref>PMID:21264284</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Huang H]] | |||
[[Category: Vogel HJ]] | |||
