Neuroligin: Difference between revisions
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New page: left|200px|thumb|Crystal Structure of human Neuroligin [[3be8]] {{STRUCTURE_3be8| PDB=3be8 | SIZE=300| SCENE= |right|CAPTION=Neuroligin 3be8 }} |
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[[ | <StructureSection load='' size='350' side='right' scene='42/422448/Cv/2' caption='Dimer of two mouse neuroligin-1 cholinesterase-like domains (magenta and cyan) in complex with two neurexin-beta1 LNS6 domains (salmon and yellow) and Ca+2 ions (green) [[3b3q]]'> | ||
{{ | |||
== Function == | |||
[[Neuroligin|Neuroligins]] (NLGN) are a family of postsynaptic proteins which bind to the presynaptic [[Neurexin]] (NRXN) to form a complex which attaches neurons. In humans the NLGN family contains 4 to 5 members that are numbered 1, 2, 3, 4X and 5 or 4Y<ref>PMID:18093521</ref>. | |||
See [[Neurodevelopmental Disorders]]<br /> | |||
[[Neuroligin-Neurexin Interaction]] | |||
*'''NLGN-1''' regulates spines and synaptic plasticity<ref>PMID:26880202</ref>. <br /> | |||
*'''NLGN-2''' is localized to inhibitory synapses<ref>PMID:15540461</ref>. <br /> | |||
*'''NLGN-3''' is a synapse organizer which shapes normal function and autism disorder<ref>PMID:17897391</ref>. <br /> | |||
*'''NLGN-4''' is localized to glyceric post-synapses and regulates retina inhibition<ref>PMID:21282647</ref>. <br /> | |||
== Disease == | |||
Mutations in NLGN 4 are associated with autism and mental retardation<ref>PMID:19726642</ref>. | |||
== Structural insights == | |||
The <scene name='42/422448/Cv/5'>NLGN-NRXN complex involves the octahedrally coordinated Ca+2 ion</scene><ref>PMID:18084303</ref>. Water molecules are shown as red spheres. | |||
</StructureSection> | |||
== 3D Structures of Neuroligin == | |||
{{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | |||
{{#tree:id=OrganizedByTopic|openlevels=0| | |||
* Neuroligin | |||
**[[5ojk]] - hNLGN-1 cholinesterase domain - human<br /> | |||
**[[3bix]] - rNLGN-1 cholinesterase domain - rat<br /> | |||
**[[8gs4]] - hNLGN-2 – Cryo EM<br /> | |||
**[[3bl8]] - mNLGN-2 cholinesterase domain – mouse<br /> | |||
**[[7cee]] - mNLGN-3 cholinesterase domain<br /> | |||
**[[3be8]] - hNLGN-4 cholinesterase domain – human<br /> | |||
* Neuroligin+neurexin | |||
**[[2xb6]], [[2wqz]] – hNLGN-4 cholinesterase domain+NRXN-1β LNS domain <br /> | |||
**[[3b3q]] - mNLGN-4 cholinesterase domain+NRXN-1β LNS domain<br /> | |||
**[[3biw]] - rNLGN-1 cholinesterase domain+NRXN-1β LNS domain<br /> | |||
**[[3vkf]] - rNLGN-1 cholinesterase domain + bNRXN-1β LNS domain | |||
*NLGN other complexes | |||
**[[5oj6]] - rNLGN-1 cholinesterase domain + MDGA1<br /> | |||
**[[9fan]], [[9far]] - hNLGN-2 TMD domain 674-696 + GABA receptor gamma2 subunit + GARLH4 – Cryo EM<br /> | |||
**[[9faj]], [[9fam]], [[9fap]], [[9faq]], [[9fau]], [[9fav]], [[9faw]], [[9fax]] - hNLGN-2 TMD domain + GABA receptor + GARLH4 + megabody – Cryo EM<br /> | |||
**[[9fat]] - hNLGN-2 TMD domain + GABA receptor + GARLH4 + megabody + pregnenolone – Cryo EM<br /> | |||
**[[9fak]] - hNLGN-2 TMD domain + GABA receptor + GARLH4 + megabody + GABA – Cryo EM<br /> | |||
**[[5v5v]] - rNLGN-2 cholinesterase domain + MDGA1<br /> | |||
**[[5xeq]] - rNLGN-2 cholinesterase domain (mutant) + MDGA1<br /> | |||
**[[7ceg]] - mNLGN-3 cholinesterase domain + PTP d<br /> | |||
}} | |||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | |||
