3myu: Difference between revisions

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[[Image:3myu.jpg|left|200px]]


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==Mycoplasma genitalium MG289==
The line below this paragraph, containing "STRUCTURE_3myu", creates the "Structure Box" on the page.
<StructureSection load='3myu' size='340' side='right'caption='[[3myu]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3myu]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MYU FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=VIB:3-(4-AMINO-2-METHYL-PYRIMIDIN-5-YLMETHYL)-5-(2-HYDROXY-ETHYL)-4-METHYL-THIAZOL-3-IUM'>VIB</scene></td></tr>
{{STRUCTURE_3myu|  PDB=3myu  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3myu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3myu OCA], [https://pdbe.org/3myu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3myu RCSB], [https://www.ebi.ac.uk/pdbsum/3myu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3myu ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/P37_MYCGE P37_MYCGE] P37 is part of a high-affinity transport system.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Mycoplasma genitalium is one of the smallest organisms capable of self-replication and its sequence is considered a starting point for understanding the minimal genome required for life. MG289, a putative phosphonate substrate binding protein, is considered to be one of these essential genes. The crystal structure of MG289 has been solved at 1.95 A resolution. The structurally identified thiamine binding region reveals possible mechanisms for ligand promiscuity. MG289 was determined to be an extracytoplasmic thiamine binding lipoprotein. Computational analysis, size exclusion chromatography, and small angle X-ray scattering indicates that MG289 homodimerizes in a concentration-dependant manner. Comparisons to the thiamine pyrophosphate binding homolog Cypl reveal insights into the metabolic differences between mycoplasmal species including identifying possible kinases for cofactor phosphorylation and describing the mechanism of thiamine transport into the cell. These results provide a baseline to build our understanding of the minimal metabolic requirements of a living organism. Proteins 2011. (c) 2010 Wiley-Liss, Inc.


===Mycoplasma genitalium MG289===
Insights into Mycoplasma genitalium metabolism revealed by the structure of MG289, an extracytoplasmic thiamine binding lipoprotein.,Sippel KH, Venkatakrishnan B, Boehlein SK, Sankaran B, Quirit JG, Govindasamy L, Agbandje-McKenna M, Goodison S, Rosser CJ, McKenna R Proteins. 2011 Feb;79(2):528-36. PMID:21117240<ref>PMID:21117240</ref>


 
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
==About this Structure==
</div>
3MYU is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Mycoplasma_genitalium Mycoplasma genitalium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MYU OCA].  
<div class="pdbe-citations 3myu" style="background-color:#fffaf0;"></div>
 
== References ==
==Reference==
<references/>
<ref group="xtra">PMID:19724130</ref><ref group="xtra">PMID:19233924</ref><ref group="xtra">PMID:19020356</ref><references group="xtra"/>
__TOC__
[[Category: Mycoplasma genitalium]]
</StructureSection>
[[Category: Agbandje-McKenna, M.]]
[[Category: Large Structures]]
[[Category: Boehlein, S K.]]
[[Category: Goodison, S]]
[[Category: Govindasamy, L.]]
[[Category: McKenna, R.]]
[[Category: Namiki, K.]]
[[Category: Quirit, J G.]]
[[Category: Rosser, C J.]]
[[Category: Sankaran, B.]]
[[Category: Satai, Y.]]
[[Category: Sippel, K H.]]
[[Category: Atp binding cassette transporter binding protein]]
[[Category: Cypl]]
[[Category: Extracytoplasmic]]
[[Category: G37]]
[[Category: Lipoprotein]]
[[Category: Mg289]]
[[Category: Mycoplasma]]
[[Category: Mycoplasma genitalium]]
[[Category: Mycoplasma genitalium]]
[[Category: P37]]
[[Category: Agbandje-McKenna M]]
[[Category: Thiamine binding protein]]
[[Category: Boehlein SK]]
[[Category: Vib binding protein]]
[[Category: Goodison S]]
 
[[Category: Govindasamy L]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:37:16 2010''
[[Category: McKenna R]]
[[Category: Namiki K]]
[[Category: Quirit JG]]
[[Category: Rosser CJ]]
[[Category: Sankaran B]]
[[Category: Satai Y]]
[[Category: Sippel KH]]
Retrieved from "https://proteopedia.org/3myu"