2l42: Difference between revisions
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==The solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae== | |||
<StructureSection load='2l42' size='340' side='right'caption='[[2l42]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l42]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L42 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L42 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l42 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l42 OCA], [https://pdbe.org/2l42 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l42 RCSB], [https://www.ebi.ac.uk/pdbsum/2l42 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l42 ProSAT]</span></td></tr> | |||
'' | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RAP1_YEAST RAP1_YEAST] Essential regulatory protein in yeast whose DNA-binding sites are found at three types of chromosomal elements: promoters, silencers, and telomeres. RAP1 is also involved in the regulation of telomere structure, where its binding sites are found within the terminal poly[C(1-3)A] sequences. The opposite regulatory functions of RAP1 are not intrinsic to its binding sites but, instead, result from interactions with different factors at promoters and silencers. RAP1 associates with SIR3 and SIR4 proteins to form a DNA-binding complex that initiates the repression at the HM loci and telomeres. May also target the binding of RIF1 and RIF2 to silencers and telomeres. Forms with GCR1 a transcriptional activation complex that is required for expression of glycolytic and ribosomal gene. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Tu X]] | |||
[[Category: Zhang J]] | |||
[[Category: Zhang W]] | |||
Latest revision as of 06:52, 1 May 2024
The solution structure of Rap1 BRCT domain from Saccharomyces cerevisiae
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