2xvc: Difference between revisions
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New page: '''Unreleased structure''' The entry 2xvc is ON HOLD Authors: Samson, R.Y., Obita, T., Hodgson, B., Shaw, M., Chong, P.L.G., Williams, R.L., Bell, S.D. Description: Molecular and struc... |
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==Molecular and structural basis of ESCRT-III recruitment to membranes during archaeal cell division== | |||
<StructureSection load='2xvc' size='340' side='right'caption='[[2xvc]], [[Resolution|resolution]] 2.15Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2xvc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharolobus_solfataricus Saccharolobus solfataricus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XVC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XVC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.15Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CD:CADMIUM+ION'>CD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xvc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xvc OCA], [https://pdbe.org/2xvc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xvc RCSB], [https://www.ebi.ac.uk/pdbsum/2xvc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xvc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/Q97ZJ6_SACS2 Q97ZJ6_SACS2] | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Members of the crenarchaeal kingdom, such as Sulfolobus, divide by binary fission yet lack genes for the otherwise near-ubiquitous tubulin and actin superfamilies of cytoskeletal proteins. Recent work has established that Sulfolobus homologs of the eukaryotic ESCRT-III and Vps4 components of the ESCRT machinery play an important role in Sulfolobus cell division. In eukaryotes, several pathways recruit ESCRT-III proteins to their sites of action. However, the positioning determinants for archaeal ESCRT-III are not known. Here, we identify a protein, CdvA, that is responsible for recruiting Sulfolobus ESCRT-III to membranes. Overexpression of the isolated ESCRT-III domain that interacts with CdvA results in the generation of nucleoid-free cells. Furthermore, CdvA and ESCRT-III synergize to deform archaeal membranes in vitro. The structure of the CdvA/ESCRT-III interface gives insight into the evolution of the more complex and modular eukaryotic ESCRT complex. | |||
Molecular and Structural Basis of ESCRT-III Recruitment to Membranes during Archaeal Cell Division.,Samson RY, Obita T, Hodgson B, Shaw MK, Chong PL, Williams RL, Bell SD Mol Cell. 2011 Jan 21;41(2):186-96. PMID:21255729<ref>PMID:21255729</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
<div class="pdbe-citations 2xvc" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Saccharolobus solfataricus]] | |||
[[Category: Bell SD]] | |||
[[Category: Chong PL]] | |||
[[Category: Hodgson B]] | |||
[[Category: Obita T]] | |||
[[Category: Samson RY]] | |||
[[Category: Shaw MK]] | |||
[[Category: Williams RL]] | |||
