2kpz: Difference between revisions

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{{Seed}}
[[Image:2kpz.jpg|left|200px]]


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==Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein Derived Peptide SDPQIPPPYVEP==
The line below this paragraph, containing "STRUCTURE_2kpz", creates the "Structure Box" on the page.
<StructureSection load='2kpz' size='340' side='right'caption='[[2kpz]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[2kpz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/HTLV-1_isolate_Mel_15 HTLV-1 isolate Mel 15] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KPZ FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kpz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kpz OCA], [https://pdbe.org/2kpz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kpz RCSB], [https://www.ebi.ac.uk/pdbsum/2kpz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kpz ProSAT]</span></td></tr>
{{STRUCTURE_2kpz|  PDB=2kpz  |  SCENE=  }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/NEDD4_HUMAN NEDD4_HUMAN] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Involved in the pathway leading to the degradation of VEGFR-2/KDFR, independently of its ubiquitin-ligase activity. Monoubiquitinates IGF1R at multiple sites, thus leading to receptor internalization and degradation in lysosomes. Ubiquitinates FGFR1, leading to receptor internalization and degradation in lysosomes. According to PubMed:18562292 the direct link between NEDD4 and PTEN regulation through polyubiquitination described in PubMed:17218260 is questionable. Involved in ubiquitination of ERBB4 intracellular domain E4ICD. Involved in the budding of many viruses. Part of a signaling complex composed of NEDD4, RAP2A and TNIK which regulates neuronal dendrite extension and arborization during development. Ubiquitinates TNK2 and regulates EGF-induced degradation of EGFR and TNF2.<ref>PMID:17218260</ref> <ref>PMID:18562292</ref> <ref>PMID:20086093</ref> <ref>PMID:21765395</ref> <ref>PMID:21399620</ref>  


===Human NEDD4 3RD WW Domain Complex with The Human T-cell Leukemia virus 1 GAG-Pro poliprotein Derived Peptide SDPQIPPPYVEP===
==See Also==
 
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 
== References ==
==About this Structure==
<references/>
2KPZ is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KPZ OCA].
__TOC__
</StructureSection>
[[Category: HTLV-1 isolate Mel 15]]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Blanco, F J.]]
[[Category: Large Structures]]
[[Category: Bonet, R.]]
[[Category: Blanco FJ]]
[[Category: Cobos, E S.]]
[[Category: Bonet R]]
[[Category: Iglesias-Bexiga, M.]]
[[Category: Cobos ES]]
[[Category: Luque, I.]]
[[Category: Iglesias-Bexiga M]]
[[Category: Macias, M.]]
[[Category: Luque I]]
[[Category: Aspartyl protease]]
[[Category: Macias M]]
[[Category: Capsid protein]]
[[Category: Complex]]
[[Category: Host-virus interaction]]
[[Category: Htlv1]]
[[Category: Human modular domain]]
[[Category: Ligase]]
[[Category: Lipoprotein]]
[[Category: Metal-binding]]
[[Category: Myristate]]
[[Category: Nedd4]]
[[Category: Phosphoprotein]]
[[Category: Protease]]
[[Category: Ubl conjugation pathway]]
[[Category: Viral nucleoprotein]]
[[Category: Virion]]
[[Category: Ww domain]]
[[Category: Zinc-finger]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:03:52 2010''
Retrieved from "https://proteopedia.org/2kpz"