3ih7: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,331,613 edits
No edit summary
 
(8 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Seed}}
[[Image:3ih7.jpg|left|200px]]


<!--
==Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA==
The line below this paragraph, containing "STRUCTURE_3ih7", creates the "Structure Box" on the page.
<StructureSection load='3ih7' size='340' side='right'caption='[[3ih7]], [[Resolution|resolution]] 3.10&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3ih7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3IH7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.1&#8491;</td></tr>
-->
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ih7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ih7 OCA], [https://pdbe.org/3ih7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ih7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ih7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ih7 ProSAT]</span></td></tr>
{{STRUCTURE_3ih7|  PDB=3ih7  |  SCENE=  }}
</table>
== Disease ==
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:[https://omim.org/entry/144700 144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.
== Function ==
[https://www.uniprot.org/uniprot/OGG1_HUMAN OGG1_HUMAN] DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.


===Crystal structure of catalytically active human 8-oxoguanine glycosylase distally crosslinked to guanine-containing DNA===
==See Also==
 
*[[DNA glycosylase 3D structures|DNA glycosylase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
3IH7 is a 3 chains structure with sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3IH7 OCA].
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
[[Category: Crenshaw, C M.]]
[[Category: Large Structures]]
[[Category: Kutchukian, P S.]]
[[Category: Crenshaw CM]]
[[Category: Oo, K S.]]
[[Category: Kutchukian PS]]
[[Category: Verdine, G L.]]
[[Category: Oo KS]]
[[Category: Disulfide crosslink]]
[[Category: Verdine GL]]
[[Category: Dna damage]]
[[Category: Dna glycosylase]]
[[Category: Dna repair]]
[[Category: Glycosidase]]
[[Category: Hydrolase]]
[[Category: Lyase]]
[[Category: Mitochondrion]]
[[Category: Multifunctional enzyme]]
[[Category: Nucleus]]
[[Category: Undamaged dna]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Nov  3 11:07:56 2010''
Retrieved from "https://proteopedia.org/3ih7"